Neurology:糖尿病与后续帕金森病之间的关系

2018-06-14 xing.T MedSci原创

由此可见,在这项大型队列研究中,研究人员报告了T2DM后PD的发生率有所增加。这些发现可能反映了他们可能共享遗传易感性和/或共享致病途径,这些结果具有潜在的临床和治疗意义。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在探讨2型糖尿病(T2DM)与后续帕金森病(PD)之间的关系。

研究人员采用英国国立医院统计和死亡率数据(1999-2011)进行了一项回顾性队列研究,构建了一个接受治疗的T2DM队列,并与参考队列进行了比较。研究人员使用Cox回归模型估计了随后的PD风险。排除了脑血管疾病、血管性帕金森综合征、药物性帕金森综合征和正常压力脑积水的个体。

该研究共有2017115人进入了T2DM队列,6173208人进入了参考队列。T2DM后PD发生率显著升高(风险比[HR] 为1.32,95%可信区间[CI]为1.29-1.35;P<0.001)。当与较年轻的个体相比(25-44岁组,HR为3.81、95%CI为2.84-5.11),复杂T2DM患者(HR为1.49、95%CI为1.42-1.56)相对增加程度更大。

由此可见,在这项大型队列研究中,研究人员报告了T2DM后PD的发生率有所增加。这些发现可能反映了他们可能共享遗传易感性和/或共享致病途径,这些结果具有潜在的临床和治疗意义。

原始出处:


Eduardo De Pablo-Fernandez,et al. Association between diabetes and subsequent Parkinson disease A record-linkage cohort study.neurology.2018. https://doi.org/10.1212/WNL.0000000000005771

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    2018-08-31 yinhl1978
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    2018-06-20 phoebeyan520

    学习了.谢谢分享

    0

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    2018-06-15 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-06-15 飛歌

    厉害了我的哥

    0

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    2018-06-14 清风拂面

    谢谢分享学习

    0

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    2018-06-14 changjiu

    学习一下谢谢

    0

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