J Biol Eng:新型纳米支架可用于生物医学工程

2018-10-11 MedSci MedSci原创

通过生物材料表面形貌引导细胞反应的能力在生物医学领域的应用十分重要。既往研究已经证实基质表面形貌是调节细胞反应的有效线索。本研究中,研究人员探究了人主动脉内皮细胞对纳米多孔阳极氧化铝和大孔硅的胶原和纤连蛋白功能化的响应。 使用共聚焦显微镜和扫描电子显微镜分析材料和孔隙率对细胞粘附、形态和增殖的影响。通过原子力显微镜表征在大孔和纳米多孔材料上的细胞铺展和丝状伪足形成。此外,我们还研究了蛋白质对

通过生物材料表面形貌引导细胞反应的能力在生物医学领域的应用十分重要。既往研究已经证实基质表面形貌是调节细胞反应的有效线索。本研究中,研究人员探究了人主动脉内皮细胞对纳米多孔阳极氧化铝和大孔硅的胶原和纤连蛋白功能化的响应。

使用共聚焦显微镜和扫描电子显微镜分析材料和孔隙率对细胞粘附、形态和增殖的影响。通过原子力显微镜表征在大孔和纳米多孔材料上的细胞铺展和丝状伪足形成。此外,我们还研究了蛋白质对粘附的影响。

结果显示,纤连蛋白功能化材料时,细胞的粘附,形态和增殖的效果最好。

总之,这些结果允许获得用于若干生物技术应用的化学修饰的3D结构,例如组织工程,片上器官或再生医学。

原始出处:

P. Formentín, Ú. Catalán, et al., Collagen and fibronectin surface modification of nanoporous anodic alumina and macroporous silicon for endothelial cell cultures. J Biol Eng. 2018; 12: 21.

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    2019-01-19 spoonycyy
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    2018-11-06 sunylz
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