Stem Cells Int:干细胞片和Bio-Oss®骨颗粒复合物联合semaphorin 3A 可用于治疗2型糖尿病患者的骨丧失

2019-09-03 不详 网络

骨组织再生被认为是骨丧失的最佳解决方案。然而,与非糖尿病患者相比,糖尿病患者骨愈合或骨移植失败的风险更大。本研究旨在探究脂肪来源干细胞片(ASC片)和Bio-Oss®骨颗粒复合物联合semaphorin 3A 对2型糖尿病(T2DM)大鼠骨愈合的影响。大鼠ASC片在体外显示出比ASC更强的成骨能力,如细胞外基质矿化和mRNA水平的成骨相关基因的表达所示。如微量计算机断层扫描(micro-CT)和组

骨组织再生被认为是骨丧失的最佳解决方案。然而,与非糖尿病患者相比,糖尿病患者骨愈合或骨移植失败的风险更大。本研究旨在探究脂肪来源干细胞片(ASC片)和Bio-Oss®骨颗粒复合物联合semaphorin 3A 对2型糖尿病(T2DM)大鼠骨愈合的影响。

大鼠ASC片在体外显示出比ASC更强的成骨能力,如细胞外基质矿化和mRNA水平的成骨相关基因的表达所示。如微量计算机断层扫描(micro-CT)和组织学分析所示,ASC片结合Bio-Oss®骨颗粒促进T2DM大鼠的骨形成。此外,Sema3A促进体外ASC片的成骨分化,局部注射Sema3A促进T2DM大鼠颅骨再生,基于ASC片和Bio-Oss®骨颗粒复合物治疗。

总之,局部注射Sema3A以及ASC片和Bio-Oss®骨颗粒的复合物可以促进骨质愈合,并且可能有助于改善T2DM患者的骨愈合。

原始出处:

Xu X, Fang K, et al., Local Application of Semaphorin 3A Combined with Adipose-Derived Stem Cell Sheet and Anorganic Bovine Bone Granules Enhances Bone Regeneration in Type 2 Diabetes Mellitus Rats. Stem Cells Int. 2019 Jul 31;2019:2506463. doi: 10.1155/2019/2506463. eCollection 2019.

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    2020-02-03 维他命
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    2020-02-18 sunylz
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topicName=骨丧失)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a0f35143673, createdName=mei543, createdTime=Sun Jul 26 16:21:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794710, encodeId=16c81e947103c, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Mar 01 03:21:00 CST 2020, time=2020-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793720, encodeId=e4711e9372075, content=<a href='/topic/show?id=dcc01612ecc' target=_blank style='color:#2F92EE;'>#Semaphorin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16127, encryptionId=dcc01612ecc, topicName=Semaphorin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sat Feb 15 01:21:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871407, encodeId=7cb818e14078c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Feb 03 16:21:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794975, encodeId=6a251e94975d8, content=<a href='/topic/show?id=46e716e82a6' target=_blank style='color:#2F92EE;'>#stem cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16782, encryptionId=46e716e82a6, topicName=stem cells)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Thu Oct 31 23:21:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025325, encodeId=17b51025325f7, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Fri Sep 06 18:21:00 CST 2019, time=2019-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317524, encodeId=5337131e524ce, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Sep 05 09:21:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
    2020-07-26 mei543
  5. [GetPortalCommentsPageByObjectIdResponse(id=1961693, encodeId=544b19616938a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Feb 03 12:21:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918842, encodeId=e5691918842c5, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, 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topicName=骨丧失)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a0f35143673, createdName=mei543, createdTime=Sun Jul 26 16:21:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794710, encodeId=16c81e947103c, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Mar 01 03:21:00 CST 2020, time=2020-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793720, encodeId=e4711e9372075, content=<a href='/topic/show?id=dcc01612ecc' target=_blank style='color:#2F92EE;'>#Semaphorin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16127, encryptionId=dcc01612ecc, topicName=Semaphorin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sat Feb 15 01:21:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871407, encodeId=7cb818e14078c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Feb 03 16:21:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794975, encodeId=6a251e94975d8, content=<a 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href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Sep 05 09:21:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1961693, encodeId=544b19616938a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Feb 03 12:21:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918842, encodeId=e5691918842c5, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, 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href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Sep 05 09:21:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
    2020-02-15 chg121
  7. 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  8. 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    2019-09-06 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  10. 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    2019-09-05 fengyi812