Hypertension:酒精消耗量与高血压患者左室舒张功能障碍相关

2016-10-20 xing.T MedSci原创

总之,酒精消耗量与非酒精性高血压患者的左室舒张功能障碍存在独立的相关性,并可能促进舒张性心脏衰竭的发展。

酒精消耗量与贪杯者左心室功能不全存在相关性,然而,高血压患者适度的酒精摄入对左室功能的影响仍然未知。近日,心血管权威杂志《Hypertension》上发表一篇旨在探讨酒精消耗量和非酒精性高血压患者心脏变化之间关系的研究文章。

在335例原发性高血压患者中,研究者采用问卷调查的方式调查了研究对象每天的酒精消耗量,以此评估了他们最近和终生酒精消耗量,通过超声心动图检查心脏结构和功能。排除肝功能异常、既往有心血管事件病史、左室射血分数小于50%以及肌酐清除率低于30ml/min/1.72m2的患者。

研究者通过组织多普勒检测发现21%的高血压病患者有左室肥厚,50%患者出现舒张功能不全。比较有无左室肥厚的高血压患者酒精消耗量,研究者发现室舒张功能不全的患者比正常心室充盈的高血压患者酒精消耗量更多。左心房内径、e′波速度、e′/a′比和E/e′比的变化随酒精消耗量的增加而恶化,当高血压患者酒精消耗量超过20g/d,患者左室舒张功能不全的发生率显著增加。酒精消耗量与e′波速度呈负相关。多因素logistic回归分析表明,酒精消耗量能够独立于年龄、体重指数、血压、胰岛素敏感性和左心室质量指数等指标预测舒张功能不全。

总之,酒精消耗量与非酒精性高血压患者的左室舒张功能障碍存在独立的相关性,并可能促进舒张性心脏衰竭的发展。

原始出处:

Cristiana Catena,et al. Moderate Alcohol Consumption Is Associated With Left Ventricular Diastolic Dysfunction in Nonalcoholic Hypertensive Patients. Hypertension.2016 Nov;68(5):1208-1216. 

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    2017-02-21 feather89
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    2016-11-30 yahu
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