AJG: 体力活动程度与非酒精性脂肪肝呈负相关

2021-12-21 MedSci原创 MedSci原创

NAFLD一般指非酒精性脂肪性肝病。 非酒精性脂肪性肝病(NAFLD)是指除外酒精和其他明确的损肝因素所致的肝细胞内脂肪过度沉积为主要特征的临床病理综合征。

非酒精性脂肪性肝病 (NAFLD) 已成为西方世界最普遍的慢性肝病,并与严重的肝和肝外合并症和死亡率相关。此外,由于肥胖和代谢综合征的迅速增加,预计未来几十年 NAFLD 的疾病负担将进一步增加。减肥和改善代谢健康是预防和疾病管理的重要目标;事实上,如果体重减轻 5%,NAFLD 甚至纤维化都可以消退。因此,许多研究调查了膳食摄入量和成分在脂肪变性消退中的潜力。此外,先前的研究表明,体育活动与 NAFLD 之间存在一定程度的有益关联。然而,目前的研究缺乏关于身体活动持续时间和强度的具体建议。同时,不同强度的活动和久坐行为的影响以及它们对 NAFLD 的影响是否可以用代谢健康来解释尚不清楚。因此,本项研究旨在探究客观测量的体力活动与基于超声的 NAFLD 之间的关联,重点是不同强度的体力活动、久坐行为以及这些关联中代谢健康的影响。

 

研究人员在荷兰鹿特丹地区基于人群的研究队列中进行了横断面分析。在 2009 年至 2014 年期间收集了所有患者的腹部超声和运动加速度计数据。NAFLD 被定义为通过超声诊断出的肝脂肪变性,并且没有导致脂肪变性的继发性原因:病毒性肝炎、脂肪性药物和过量饮酒。最后研究人员将加速度计数据分为久坐时间和轻度、中度和剧烈的体力活动,然后分析了不同运动形式与NAFLD的关系。

 

本项研究总共纳入了 667 名参与者(年龄 63.3±6.3 岁,53%为女性),34.3%患有 NAFLD。调整了人口、生活方式和社会经济因素后,总体力活动与较低的 NAFLD 患病率相关(HR:0.958  10min/天,95% [CI]:0.929-0.986)。更密集的体力活动与较低的 NAFLD 患病率更密切相关:轻、中和剧烈体力活动的比值比为 0.931 (95% CI: 0.882–0.982)、0.891 (95% CI: 0.820–0.967) 和 0.740 ( 95% CI:0.600–0.906)  10min/天。

 

本项研究证实每种强度的体力活动与 NAFLD 患病率呈负相关,而且对更高强度的体力活动影响更大。这种关联是由更好的代谢健康介导的,主要是较低的胰岛素抵抗和腰围。因此,体育活动应纳入 NAFLD 疾病管理和预防计划。

原始出处:

van Kleef, Laurens A. et al. Objectively Measured Physical Activity Is Inversely Associated With Nonalcoholic Fatty Liver Disease: The Rotterdam Study. The American Journal of Gastroenterology.2021.

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    2022-12-02 minzju5052
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    2021-12-22 hmwwww

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