Nature:新冠mRNA疫苗I期临床试验在美国开展

2020-03-18 佚名 生物探索

COVID-19疫苗——mRNA疫苗已在美国开始第一期临床试验。

COVID-19疫情爆发以来,已感染成千上万人,并造成数***死亡,目前我国的疫情得到较好的控制,但疫情在国外的蔓延势头仍让人不寒而栗。治疗新冠肺炎、开发疫苗是当前迫切需要解决的一项重要使命。近日,《Nature》报道,COVID-19疫苗已在美国开始第一期临床试验,这既是个重要的里程碑,也是证明药物安全性和有效性的漫长历程的开始。

doi:10.1038/d41586-020-00154-w

这个候选疫苗的代号为mRNA-1273,是由美国国家过敏及传染疾病研究所(the US National Institute of Allergy and Infectious Diseases, NIAID)和马萨诸塞州的生物技术公司Moderna合作开发的。该疫苗不含冠状病毒,而是以mRNA为主,指导人体产生类似新冠病毒表面的蛋白,以期引发免疫反应,同时防止感染。

在该试验中,研究者首先对45名参与者中的4名人员注射该疫苗第一剂,然后在接下来的六周内,给其他参与者注射不同的第一剂疫苗,最后在28天后注射第二剂。与此同时,研究者将亲自或通过电话作后续访问,评估参与者在14个月内的健康状况,也会通过血液样本来评估人体对该疫苗的免疫反应。

疫苗的第一阶段安全性研究临床试验。图片来源:Ted S. Warren

NIAID总监Anthony Fauci在 3月16日声明 “COVID-19疫苗临床试验第一期”以“创纪录的速度”启动,从病毒的基因测序到候选疫苗的首次注射仅用了63天。研究人员希望能在三个月内获得初步的临床试验数据。但同时表示,即使研究进展顺利,疫苗也不会在12~18个月内得到广泛使用。

此外,科学家表示,候选疫苗mRNA-1273不是正在开发的唯一潜在疫苗,目前世界各地数十个研究小组正在竞相研发COVID-19的疫苗,InovioPharmaceuticals开发的另一种候选疫苗有望下个月在美国、中国和韩国开始安全性研究。

原始出处:

Coronavirus latest: First vaccine clinical trials begin in United States. Nature, 2020.

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    2021-03-03 liye789132251
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    2020-03-18 公卫新人

    新冠肺炎,疫情何时才能消失

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