Dement Geriatr Cogn Dis Extra：老年康复患者神经精神症状患病率高

　　近期Dement Geriatr Cogn Dis Extra网络版发表的一项多中心横断面研究的结果显示，在康复中心接受治疗的老年康复患者神经精神症状的患病率处于较高水平，但仍低于在门诊老年患者的患病率。

　　研究为确定神经精神症状在老年康复患者中的发病率，研究者对其中痴呆和非痴呆患者的神经精神症状进行了对比，并评估了患者认知损害严重程度与神经精神症状之间的联系。

　　2009年2月，研究者对在巴黎四家老年康复中心中接受治疗的年龄在75岁及以上的老人进行了研究，研究采用的12项精神神经量表项目及评估的四种亚综合征均经欧洲阿尔兹海默氏病协会审定。

　　共194名患者参加研究，其中的149名（占参与者总数的78.6%）有痴呆症状，154名（占参与者总数的79.4%）在研究前一周至少出现过一种神经精神症状。痴呆组中最普遍的神经精神症状是焦虑不安（占该组人数的36.9%），非痴呆组中是抑郁（占该组人数的35.6%）。多动（P<0.001）和妄想（P=0.01）在痴呆组中的患病率显著高于非痴呆组。在痴呆组中认知损害的严重程度与多动（P=0.01）及精神疾病（P=0.02）有关。

Neuropsychiatric Symptoms in Elderly Inpatients: A Multicenter Cross-Sectional Study
Abstract
Background/Aims: We determined the prevalence of neuropsychiatric symptoms in geriatric rehabilitation patients to compare neuropsychiatric symptoms between patients with and without dementia, and to evaluate associations linking severity of cognitive impairment and neuropsychiatric symptoms. Methods: In February 2009, we studied patients aged 75 years or older who had been admitted to four geriatric rehabilitation units in the Paris area. The twelve Neuropsychiatric Inventory items and four neuropsychiatric subsyndromes defined by the European Alzheimer's Disease Consortium were evaluated. Results: Of the 194 patients, 149 (76.8%) had dementia, and 154 (79.4%) had exhibited at least one neuropsychiatric symptom during the past week. Agitation was the most common neuropsychiatric symptom in the group with dementia (36.9%) and depression in the group without dementia (35.6%). The dementia group had significantly higher prevalences of hyperactivity (p < 0.001) and delusions (p = 0.01) than the non-dementia group. In the dementia group, severity of cognitive impairment was associated with hyperactivity (p = 0.01) and psychosis (p = 0.02). Conclusion: The prevalence of neuropsychiatric symptoms among geriatric rehabilitation patients was high but not higher than in elderly outpatients.