Clinica Chimica Acta:SARS-CoV-2患者的心肌肌钙蛋白I:连续监测的附加预后价值

2021-01-04 MedSci原创 MedSci原创

已经有研究报道了SARS-CoV-2患者的主要心脏并发症。研究心肌肌钙蛋白的动态释放是区分急性和慢性损伤的推荐方法,以便于临床处理不同的心脏疾病。

已经有研究报道了SARS-CoV-2患者的主要心脏并发症。研究心肌肌钙蛋白的动态释放是区分急性和慢性损伤的推荐方法,以便于临床处理不同的心脏疾病。本研究探讨高敏感性肌钙蛋白I (hs-cTnI)的连续测量是否可能为SARS-CoV-2患者的临床管理提供额外信息。

研究人员对113例经微生物学证实感染患者进行了研究。使用STAT高灵敏度肌钙蛋白I (Architect i2000, Abbott Diagnostics)在锂肝素血浆样本中测量了Hs-cTnI,女性和男性0.99百分位Hs-cTnI分别为16和34 ng/L。

在113例患者中有69例测定了hs-cTnI,其中31例(45%)的hs-cTnI至少有一次高于第99个百分位数。对50名患者(72%)进行了动力学评估(在24小时内至少进行了2次测量)。将患者分为5组:hs-cTnI无监测组44例,hs-cTnI无监测组19例,监测期间无明显变化3例(n=15),持续低于或有时高于99百分位数的显著变化4例(n=8),有时高于99百分位数的5例(n=27)。第5组患者住院天数较长(中位数37天,p=0.0001),病情较重(6/27,22%,死亡),更经常需要住ICU(n=25,92.6%,0.0001),并出现一个或多个峰值,有时出现严重缺氧。

在SARS-CoV-2患者中,hs-cTnI连续监测可能提供额外的数据,以分层风险,建立预后,并获得关于心脏与这一大流行性疾病的流行病学的相关性。

原始出处:

Martina Zaninotto,Monica Maria Mion,Cardiac troponin I in SARS-CoV-2-patients: The additional prognostic value of serial monitoring

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    2021-04-29 hukaixun
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    2021-04-25 windight
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    2021-01-05 小刀医生
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