NEJM:白介素-1阻滞剂Rilonacept用于复发性心包炎的治疗

2021-01-07 MedSci原创 MedSci原创

Rilonacept可快速缓解复发性心包炎患者临床症状,同时降低复发风险

急性心包炎初次发作后,多达30%的患者可能发生复发,研究证实白细胞介素-1在复发性心包炎病理过程中发挥重要作用。近日研究人员开展III期研究,考察了白介素-1(IL-1)阻滞剂 Rilonacept对复发性心包炎患者的疗效和安全性。
 
复发性心包炎患者参与研究,C反应蛋白水平显示患者存在全身炎症,患者首先接受为期12周的标准治疗,在标准治疗期间,逐步以Rilonacept代替其他治疗药物,对Rilonacept治疗有应答的患者随机继续接受Rilonacept治疗或安慰剂。研究的主要终点心包炎首次复发时间。
 
86名患者参与研究,患者CRP水平升高,并伴有心包炎疼痛。在标准治疗期间,患者平均5天后疼痛消失或缓解,平均7天后C反应蛋白水平恢复正常。
61名患者接受后续分组,研究发现,Rilonacept组心包炎复发率较低,无法计算平均复发时间,而安慰剂组的平均复发时间为8.6周(HR=0.04)。Rilonacept组30名患者中,2人心包炎复发(7%),而安慰剂组31名患者中23人复发(74%)。Rilonacept组4名患者因不良事件停药,最常见的不良事件为注射部位反应和上呼吸道感染
 
研究认为,Rilonacept可快速缓解复发性心包炎患者临床症状,同时降低复发风险
 
原始出处:
 
Allan L. Klein et al. Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis . N Engl J Med,January 7, 2021.

 

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    2021-03-16 shanyongle
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    2021-03-18 zhyy88
  4. 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createdBy=54e731968959, createdName=12498f6em17暂无昵称, createdTime=Tue Jun 01 00:24:35 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085850, encodeId=8278208585072, content=<a href='/topic/show?id=723a9e69383' target=_blank style='color:#2F92EE;'>#阻滞剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97693, encryptionId=723a9e69383, topicName=阻滞剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Thu Mar 18 20:24:35 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779328, encodeId=334d1e79328c5, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Fri Jun 25 05:24:35 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651345, encodeId=0f32165134550, content=<a href='/topic/show?id=6eefe162275' target=_blank style='color:#2F92EE;'>#白介素-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71622, encryptionId=6eefe162275, topicName=白介素-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859f24174096, createdName=zhangph, createdTime=Tue Oct 12 10:24:35 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909861, encodeId=d533190986107, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Apr 10 08:24:35 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957294, encodeId=4d7b195e294dc, content=<a href='/topic/show?id=6111425386f' target=_blank style='color:#2F92EE;'>#复发性心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42538, encryptionId=6111425386f, topicName=复发性心包炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Sun Mar 21 02:24:35 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778952, encodeId=5d7d1e7895263, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Dec 23 07:24:35 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372148, encodeId=86ab13e214894, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416156, encodeId=ad8814161564d, content=<a href='/topic/show?id=f8db509110b' target=_blank style='color:#2F92EE;'>#心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50911, encryptionId=f8db509110b, topicName=心包炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0a83138883, createdName=zhao4617, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-06-25 xiaoyeshuang
  5. [GetPortalCommentsPageByObjectIdResponse(id=1656043, encodeId=941016560431b, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Mar 16 13:24:35 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715618, encodeId=e4a11e156187a, content=<a href='/topic/show?id=37c0154e8c2' target=_blank style='color:#2F92EE;'>#Rilonacept#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15478, encryptionId=37c0154e8c2, topicName=Rilonacept)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e731968959, createdName=12498f6em17暂无昵称, createdTime=Tue Jun 01 00:24:35 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085850, encodeId=8278208585072, content=<a href='/topic/show?id=723a9e69383' target=_blank style='color:#2F92EE;'>#阻滞剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97693, encryptionId=723a9e69383, topicName=阻滞剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Thu Mar 18 20:24:35 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779328, encodeId=334d1e79328c5, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Fri Jun 25 05:24:35 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651345, encodeId=0f32165134550, content=<a href='/topic/show?id=6eefe162275' target=_blank style='color:#2F92EE;'>#白介素-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71622, encryptionId=6eefe162275, topicName=白介素-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859f24174096, createdName=zhangph, createdTime=Tue Oct 12 10:24:35 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909861, encodeId=d533190986107, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Apr 10 08:24:35 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957294, encodeId=4d7b195e294dc, content=<a href='/topic/show?id=6111425386f' target=_blank style='color:#2F92EE;'>#复发性心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42538, encryptionId=6111425386f, topicName=复发性心包炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Sun Mar 21 02:24:35 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778952, encodeId=5d7d1e7895263, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Dec 23 07:24:35 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372148, encodeId=86ab13e214894, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416156, encodeId=ad8814161564d, content=<a href='/topic/show?id=f8db509110b' target=_blank style='color:#2F92EE;'>#心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50911, encryptionId=f8db509110b, topicName=心包炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0a83138883, createdName=zhao4617, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1656043, encodeId=941016560431b, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Mar 16 13:24:35 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715618, encodeId=e4a11e156187a, content=<a href='/topic/show?id=37c0154e8c2' target=_blank style='color:#2F92EE;'>#Rilonacept#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15478, encryptionId=37c0154e8c2, topicName=Rilonacept)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Apr 10 08:24:35 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957294, encodeId=4d7b195e294dc, content=<a href='/topic/show?id=6111425386f' target=_blank style='color:#2F92EE;'>#复发性心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42538, encryptionId=6111425386f, topicName=复发性心包炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, 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topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416156, encodeId=ad8814161564d, content=<a href='/topic/show?id=f8db509110b' target=_blank style='color:#2F92EE;'>#心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50911, encryptionId=f8db509110b, topicName=心包炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0a83138883, createdName=zhao4617, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1656043, encodeId=941016560431b, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Mar 16 13:24:35 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715618, encodeId=e4a11e156187a, content=<a href='/topic/show?id=37c0154e8c2' target=_blank style='color:#2F92EE;'>#Rilonacept#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15478, encryptionId=37c0154e8c2, topicName=Rilonacept)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdTime=Sun Mar 21 02:24:35 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778952, encodeId=5d7d1e7895263, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Dec 23 07:24:35 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372148, encodeId=86ab13e214894, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416156, encodeId=ad8814161564d, content=<a href='/topic/show?id=f8db509110b' target=_blank style='color:#2F92EE;'>#心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50911, encryptionId=f8db509110b, topicName=心包炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0a83138883, createdName=zhao4617, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1656043, encodeId=941016560431b, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Mar 16 13:24:35 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715618, encodeId=e4a11e156187a, content=<a href='/topic/show?id=37c0154e8c2' target=_blank style='color:#2F92EE;'>#Rilonacept#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15478, encryptionId=37c0154e8c2, topicName=Rilonacept)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdTime=Sun Mar 21 02:24:35 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778952, encodeId=5d7d1e7895263, content=<a href='/topic/show?id=c33118392a' target=_blank style='color:#2F92EE;'>#ACEP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1839, encryptionId=c33118392a, topicName=ACEP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Dec 23 07:24:35 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372148, encodeId=86ab13e214894, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416156, encodeId=ad8814161564d, content=<a href='/topic/show?id=f8db509110b' target=_blank style='color:#2F92EE;'>#心包炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50911, encryptionId=f8db509110b, topicName=心包炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0a83138883, createdName=zhao4617, createdTime=Sat Jan 09 10:24:35 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-12-23 xiaoyeshuang
  9. 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  10. 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Rilonacept是每周一次的皮下注射重组融合蛋白,可阻断IL-1α和IL-1β信号传导。

Nature:颠覆传统认知 解答白介素-1α免疫学谜团

日前,来自圣裘德儿童研究医院(St. Jude Children's Research Hospital)的研究人员解开了 SHP-1 基因突变导致多种炎症和自身免疫性疾病的谜团。 【原文下载】 研究人员还发现:不同形式的白细胞介素-1(IL-1)通过不同的线路促进了炎症。这一发现颠覆了当前普遍认为 IL-1α 和 IL-1β 通过相同的信号通路发挥作用的观点。 研究人员兴奋地表示,这些