Arthritis Rheumatol:痛风中的病因特异性死亡率

2019-06-10 xiangting MedSci原创

痛风患者中一些非CV病因的死亡率升高,这突出了改善合并症治疗的需要。

这项研究旨在探讨与一般人群相比,痛风患者除心血管(CV)疾病以外的病因特异性死亡率。

纳入2002年Sk?ne(瑞典)18岁以上的所有居民,研究人员使用Sk?ne医疗登记,确定了新诊断的痛风患者(2003-2013),并根据年龄和性别将1个痛风患者与10个无痛风的对照进行匹配。使用来自死因登记(截至2014 年12月31 日)的死因信息,在多状态Cox模型中调整潜在混杂因素后,估算了特定死因的死亡率风险比(HR)。

在832,258人中,有19,497人新诊断为痛风(32%为女性),并与194,947名对照者进行匹配。痛风患者慢性肾病、代谢和CV合并症的患病率较高。总体上,痛风与全因死亡率(HR 1.17,95%可信区间1.14-1.21)升高17%相关,女性升高23%(HR 1.23,1.17-1.30),男性升高15%(HR 1.15,1.10-1.19)。就病因特异性死亡率而言,痛风与肾病(HR 1.78,1.34-2.35)、消化系统疾病(HR 1.56,1.34-1.83)、CV疾病(HR 1.27,1.22-1.33)、感染(HR 1.20,1.06-1.35)、痴呆(HR 0.83,0.72-0.97)导致死亡风险的相关性最强。

痛风患者中一些非CV病因的死亡率升高,这突出了改善合并症治疗的需要。

原始出处:

Ana Beatriz Vargas‐Santos. Cause‐Specific Mortality in Gout: Novel Findings of Elevated Risk of Non‐Cardiovascular Related Deaths. Arthritis Rheumatol. 06 June 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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