Diabetes Care:骨钙素与糖尿病和糖尿病肾病的风险

2022-01-30 MedSci原创 MedSci原创

较低的OC水平与发生糖尿病和DKD的风险增加相关。

随着对新陈代谢的了解不断增加,骨来源因子和激素作为能量代谢的重要调节因子。骨钙素(OC)是骨基质中含量最丰富的非胶原蛋白,由成骨细胞合成,不仅是骨形成的标志物,而且它是一种参与调节糖脂代谢的代谢活性激素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估OC与糖尿病发病风险和糖尿病肾病 (DKD) 发病风险之间的关系。

研究人员在基线时随访了5396名没有糖尿病的参与者(非糖尿病亚组)和1174名患有糖尿病且肾功能正常的参与者(糖尿病亚组)。研究人员采用Logistic回归和改进的泊松回归模型评估了基线OC水平与糖尿病和DKD相对风险(RR)之间的关系。

在平均时间长达4.6年的随访期间,研究人员确定了296例新发糖尿病患者和184例新发DKD患者。在非糖尿病亚组中,较高的OC水平与糖尿病风险降低呈线性相关(OC浓度对数转换每增加1个单位的RR为0.51[95%CI为0.35-0.76];最高四分位数与最低四分位数相比的RR为0.65[95%CI为0.44–0.95];趋势P<0.05)。在糖尿病亚组中,OC水平与DKD呈线性负相关(OC浓度对数转换每增加1个单位的RR为0.49[95%CI为0.33–0.74];最高四分位数与最低四分位数相比的RR为0.56[95%CI为0.38–0.83];趋势P<0.05),但与基线估计的肾小球滤过率和尿白蛋白与肌酐比无关。研究人员没有观察到OC水平和各种亚组在糖尿病或DKD事件上显著的相互作用。

由此可见,较低的OC水平与发生糖尿病和DKD的风险增加相关。

原始出处:
 
Feifei Cheng,et al.Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis.Diabetes care.2022.https://diabetesjournals.org/care/article/doi/10.2337/dc21-1609/141023/Shortened-Leukocyte-Telomere-Length-Is-Associated

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    2022-02-08 419040982

    0

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    2022-01-30 查查佳佳

    杂志Stroke上发表了一篇研究文章,

    0

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