DIABETOLOGIA：1989- 2013年25年间26个欧洲中心儿童1型糖尿病发病率趋势和周期性变化：多中心前瞻性登记研究

2019-04-03 不详网络

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在儿童1型糖尿病发病率普遍增加的背景下，一些国家最近的报告显示这种增加的速度有所放缓。偶尔的报告还描述了发病率的周期性变化，周期为4至6年。

本研究报告了在1989年期间在地理上确定的地区登记新诊断个人长达25年的26个欧洲中心（代表22个国家）的0至14岁年龄组的年龄/性别标准化发病率。利用泊松回归估计增长率和周期性模式的测试。Joinpoint回归软件用于将分段对数线性关系拟合到发生率趋势。

结果显示，除两个小型中心外，其它研究单位的发生率均显著增加，波兰中心每年最高增幅为6.6％。高发国家的一些中心近年来表现出增长率减少。尽管如此，所有中心的汇总分析显示，发病率每年增加3.4％（95％CI 2.8％，3.9％），尽管有人认为2004 - 2008年期间的增长率有所下降。0至4岁年龄组男孩和女孩的增长率相似分别为（分别为3.7％和3.7％）和5至9岁年龄组（每年3.4％和3.7岁），但在10至14岁年龄组中男孩比女孩高（分别为3.3％和2.6％）。在四个中心检测到4年为重要的周期时间。

尽管儿童1型糖尿病发病率在一些高风险国家的有所下降，但各中心的汇总估计数仍然显示每年增加3.4％的发病率，这表明欧洲大约20年内发病率翻了一番。虽然四个中心显示支持4年的的周期性发病模式，但尚缺乏合理的解释。

原始出处：

Christopher C. Patterson, Valma Harjutsalo,Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989–2013: a multicentre prospective registration study

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2019-12-22 ms9608593228839890

#DIA#

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2019-10-13 luoxiaog

#多中心#

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2020-01-31 1508842480_96220437

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2019-11-14 lifestar

#发病率#

38 0
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2019-09-19 ms5439512287675881

#BET#

28 0
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2019-04-05 ms9474365431325850

#欧洲#

33 0
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2019-04-03 misszhang

谢谢MedSci提供最新的资讯

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DIABETOLOGIA：1989- 2013年25年间26个欧洲中心儿童1型糖尿病发病率趋势和周期性变化：多中心前瞻性登记研究

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