Eur Respir J:苯二氮卓类和阿片类药物在间质性肺病中的安全性

2018-12-07 xing.T MedSci原创

这项研究首次在支持采用阿片类药物和低剂量BDZ治疗的呼吸系统疾病的重症患者中,评估了BDZ和阿片类药物使用与ILD伤害之间的关系。

安全性问题是间质性肺病(ILD)患者给予苯二氮卓类药物(BDZs)和阿片类药物治疗的障碍。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员评估了BDZs和阿片类药物与患者入院和死亡风险之间的关系。

研究人员对2005年10月至2014年12月期间在瑞典开始长期氧疗的纤维化ILD患者进行了一项基于人群的纵向队列研究,并使用Fine-Gray和Cox回归分析了BDZs和阿片类药物对患者入院率和死亡率的影响,同时调整了潜在的混杂因素。

研究人员纳入了1603名患者(61%为女性)。196名(12%)患者服用BDZ治疗,254名(15%)患者服用阿片类药物治疗。BDZ与入院人数增加之间没有关联。相比于低剂量BDZ治疗,高剂量BDZ治疗与死亡率增加相关(子分布风险比(SHR)为1.46,95%CI为1.08-1.98 vs. 1.13,95%CI为0.92-1.38)。阿片类药物与入院率增加无关。低剂量阿片类药物(≤30mg/天的口服吗啡当量)(SHR为1.18,95%CI为0.96-1.45)和高剂量阿片类药物(>30mg/天的口服吗啡当量)(SHR为1.11,95%CI为0.89-1.39)均与死亡率增加无关。

这项研究首次在支持采用阿片类药物和低剂量BDZ治疗的呼吸系统疾病的重症患者中,评估了BDZ和阿片类药物使用与ILD伤害之间的关系。

原始出处:

Sabrina Bajwah, et al.Safety of benzodiazepines and opioids in interstitial lung disease: a national prospective study.Eur Respir J.2018. http://erj.ersjournals.com/content/52/6/1801278

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    2019-07-08 amy0559
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    2018-12-09 lhlxtx
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    2018-12-07 lietome2

    不错的作品,为我们探讨研究提供了方针,必须给点个赞了!

    0