Am J Rhinol Allergy:儿童过敏性鼻炎诊断的皮刺测试与Phadiatop比较

2020-07-17 AlexYang MedSci原创

皮刺测试(SPT)或者Phadiatop(一种多过敏原lgE筛选测试)是检测气源性致敏原敏感的工具。最近,有研究人员以鼻激发测试(NPT)为标准,比较了SPT和Phadiatop在诊断过敏性鼻炎(AR

皮刺测试(SPT)或者Phadiatop(一种多过敏原lgE筛选测试)是检测气源性致敏原敏感的工具。最近,有研究人员以鼻激发测试(NPT)为标准,比较了SPT和Phadiatop在诊断过敏性鼻炎(AR)中的表现情况。

研究包括了140名儿童,平均年龄为9.8±3岁,56%的为男性。其中,92名儿童(65.7%)对实验中的任何气源性致敏原均显示SPT阳性,其中88名儿童(95.6%)对屋尘螨(HDM)敏感。NPT结果表明97名儿童(69.3%)为阳性。48名儿童表现为SPT阴性的儿童中,4名儿童(8.3%)对气源性致敏原具有slgE,但NPT结果只在1名儿童中为阳性。88名儿童(62.9%)中Phadiatop结果为阳性,其中4名(4.5%)对Der p.的NPT结果为阴性。在52名Phadiatop结果为阴性的儿童中,4名儿童(7.6%)对气源性致敏原具有slgE,但是NPT结果在2名儿童(3.8%)中阳性。SPT和Phadiatop结果显示出了94.2%的一致性(Kappa 0.876, p<0.001)。使用NPT作为AR诊断的比较标准时,SPT的敏感性和特异性分别为89.6%和88.3%;Phadiatop分别为88.6%和95.3%。

最后,研究人员指出,气源性致敏原的SPT和Phadiatop在诊断儿童AR方面的敏感性和特异性是相当的。

原始出处:

Sasiwimon Traiyan, Wiparat Manuyakorn, Watcharoot Kanchongkittiphon et al. Skin Prick Test Versus Phadiatop as a Tool for Diagnosis of Allergic Rhinitis in Children. Am J Rhinol Allergy. 27 June 2020.

 

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    2020-08-03 zutt
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