BMC Gastroenterology:粪便菌群移植可用于治疗溃疡性结肠炎

2019-10-13 不详 MedSci原创

粪便菌群移植可能有助于溃疡性结肠炎的疾病缓解;但是,决定治疗效果的因素仍然未知。本研究的目的是前瞻性研究粪便微生物群移植在溃疡性结肠炎患者中的临床疗效,并确定与临床缓解相关的细菌特征。

背景
粪便菌群移植可能有助于溃疡性结肠炎的疾病缓解;但是,决定治疗效果的因素仍然未知。本研究的目的是前瞻性研究粪便微生物群移植在溃疡性结肠炎患者中的临床疗效,并确定与临床缓解相关的细菌特征。

方法
这项前瞻性和非对照研究共纳入了20例溃疡性结肠炎患者。所有患者均接受镜检查五次,每3周一次。临床指标用于评估粪便微生物群移植的疗效,以及Mayo评分,该评分用于评估溃疡性结肠炎患者肠道粘膜病变程度。通过16S核糖体RNA测序检测肠道菌群的变化,并分析溃疡性结肠炎与肠道菌群的关系。

结果
使用粪菌移植治疗后,患者腹泻,腹痛和血便的临床指数评分显着降低(p<0.05)。红细胞沉降率和C反应蛋白水平未见明显变化。但是,肠道粘膜病变的临床指标评分和Mayo评分明显降低。此外,通过16S核糖体RNA测序显示,诊断为溃疡性结肠炎的患者的肠道菌群与供体的肠道菌群不同。

结论
粪便微生物群移植对溃疡性结肠炎具有潜在的治疗价值,因为它改变了细菌性菌群的丰富度,并改善了该病患者的腹泻,腹痛和粘膜损伤评分。

原始出处:
Yan Tian. Et al. Fecal microbiota transplantation for ulcerative colitis: a prospective clinical study. BMC Gastroenterology.2019.

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  5. 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time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468135, encodeId=21b1146813549, content=<a href='/topic/show?id=ab52e63254e' target=_blank style='color:#2F92EE;'>#粪便菌群移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76325, encryptionId=ab52e63254e, topicName=粪便菌群移植)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 15 14:18:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504814, encodeId=f07c150481402, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 15 14:18:00 CST 2019, time=2019-10-15, status=1, ipAttribution=)]
    2020-05-27 nymo
  6. 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  7. 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time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468135, encodeId=21b1146813549, content=<a href='/topic/show?id=ab52e63254e' target=_blank style='color:#2F92EE;'>#粪便菌群移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76325, encryptionId=ab52e63254e, topicName=粪便菌群移植)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 15 14:18:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504814, encodeId=f07c150481402, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 15 14:18:00 CST 2019, time=2019-10-15, status=1, ipAttribution=)]
    2019-10-15 Homburg
  8. 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