JACC:氟哌啶酮PET在冠心病诊断有良好的安全性和有效性

2020-07-24 MedSci原创 MedSci原创

氟-18氟哌啶酮是一种新型的正电子发射断层扫描(PET)心肌灌注成像示踪剂。这项研究旨在评估氟吡哌酮PET与tech 99m标记的单光子发射计算机断层扫描SPECT在检测和评估冠状动脉疾病(CAD)方

氟-18氟哌啶酮是一种新型的正电子发射断层扫描(PET)心肌灌注成像示踪剂。这项研究旨在评估氟吡哌酮PET与tech 99m标记的单光子发射计算机断层扫描SPECT在检测和评估冠状动脉疾病(CAD)方面的诊断效力。

在本次临床三期试验中,纳入分析了来自72个医学中心的795名确诊或疑似CAD的患者,最终有755名患者可评估,平均年龄是62.3 ± 9.5岁,女性占31%,55%患者BMI≥30Kg/m2,71%有药理应激反应。氟吡哌酮PET对CAD的敏感度为71.9%,明显高于SPECT的53.7%(p < 0.001),而特异性未达到预定的非劣效性标准(76.2%[95%CI:71.8%至80.1%]与86.6%[95%CI:83.2%至89.8%];p >0.05)。氟吡哌酮PET在缺陷大小(p <0.001),图像质量(p <0.001),诊断确定性(p <0.001)和放射线暴露(6.1±0.4 mSv与13.4±3.2 mSv; p <0.001)方面均优于SPECT。另外,氟吡哌酮PET安全且病人耐受。

研究结果显示,氟-18氟哌啶酮PET在冠心病诊断方面表现出了良好的安全性和有效性。

原始出处:

Jamshid M et al.Phase-III Clinical Trial of Fluorine-18 Flurpiridaz Positron Emission Tomography for Evaluation of Coronary Artery Disease.JACC.2020 July.

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    2020-12-10 hbwxf
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    2020-12-13 feather89
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    2020-07-24 神盾医疗局局长Jack

    安全性不错

    0

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    2020-07-24 mswert122

    消灭零回复😀

    0

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