Semin Arthritis Rheu:小肠活检结果符合乳糜泻的特发性炎症性肌病

2021-09-09 xiangting MedSci原创

既往曾有病例报道描述了特发性炎症性肌病(IIM) 伴乳糜泻患者 (CeD) 在开始无麸质饮食后 (GFD),IIM 的肌肉炎症也有所改善。但是,IIM与CeD 之间的关联仍不清楚。

既往曾有病例报道描述了特发性炎症性肌病(IIM) 伴乳糜泻患者 (CeD) 在开始无麸质饮食后 (GFD),IIM 的肌肉炎症也有所改善。但是,IIM与CeD 之间的关联仍不清楚。这项研究首次针对该主题进行了系统评价。

研究人员在 MEDLINE、PubMed 和 EMBASE 数据库进行了系统的文献检索,并通过谷歌和谷歌学术辅助筛选参考文献。

结果共发现 1976 年至 2017 年间报道的30个病例。19名患者在诊断CeD 前有可用的胃肠道症状信息,其中 6/19名患者 (32%) 报告没有胃肠道症状。23/30名患者有与 CeD 相关的血清学数据。 10/18 名患者(56%) 存在肌内膜抗体,而只有 2/9名患者 (22%) 存在组织转谷氨酰胺酶抗体。16/18名患者 (89%) 存在天然醇溶蛋白的血清抗体。24 名患者报告 GFD 对 IIM 有临床疗效,14/24名患者 (58%) 有改善迹象,其中包括3名难治性包涵体肌炎患者。纵向随访数据表明,7/24名患者(29%) 仍处于IIM 临床缓解期,并以GFD 作为唯一的治疗。

IIM伴乳糜泻的患者特征

在这些IIM 病例中,十二指肠活检结果符合乳糜泻的患者有时并没有典型的 CeD 症状或 CeD 血清学阴性,并且在大多数情况下,开始无麸质饮食后,IIM有所改善。 虽然需要对 IIM 患者的 CeD 格外警惕,但需要更多的研究来阐明 GFD 是否对 IIM 患者小肠以外的器官也有影响。

原始出处:

Gunhild Alvik Nyborg. Small intestinal biopsy findings consistent with celiac disease in patients with idiopathic inflammatory myopathy: Review of existing literature. Semin Arthritis Rheu. September 2021.

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1972767, encodeId=cca419e2767ac, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Oct 26 19:43:54 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894818, encodeId=959f18948180e, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Feb 02 19:43:54 CST 2022, time=2022-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1724383, encodeId=218a1e2438326, content=<a href='/topic/show?id=13896e88231' target=_blank style='color:#2F92EE;'>#特发性炎症性肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67882, encryptionId=13896e88231, topicName=特发性炎症性肌病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=397a33615269, createdName=bbjsj_1990, createdTime=Wed Apr 20 01:43:54 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278246, encodeId=b4ca12e824692, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Sep 11 01:43:54 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357781, encodeId=646e135e78110, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Sep 11 01:43:54 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547469, encodeId=89cc154e469c9, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sat Sep 11 01:43:54 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622497, encodeId=4224162249ef8, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Sep 11 01:43:54 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016023, encodeId=2c09101602334, content=这个挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/55f15b58d91d45c09faf0272721b59d8/b8f36c2def38403ab9fdabaae56a939c.jpg, createdBy=f0935399328, createdName=mengmeng05116, createdTime=Thu Sep 09 11:52:59 CST 2021, time=2021-09-09, status=1, ipAttribution=)]
    2021-09-11 smlt2008
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    2021-09-11 仁者大医
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    2021-09-09 mengmeng05116

    这个挺好

    0

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