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Blood：脂质代谢增强介导了NK细胞在淋巴瘤中的功能受损

2020-09-01 MedSci原创 MedSci原创

淋巴瘤NK细胞脂质代谢
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NK细胞在血液恶性肿瘤中具有重要的保护作用，但NK细胞可以获得一种功能失调的状态，在该状态下，其抗肿瘤免疫活性受限。但迄今为止，NK细胞这种功能受损的潜在原因仍未明确。

中心点：

在B细胞淋巴瘤中，NK细胞的功能受损与脂质积累有关。

NK细胞可增强脂质代谢，以适应血脂丰富的癌症环境。

摘要：

NK细胞在血液恶性肿瘤中具有重要的保护作用，但NK细胞可以获得一种功能失调的状态，在该状态下，其抗肿瘤免疫活性受限。但迄今为止，NK细胞这种功能受损的潜在原因仍未明确。

近期，Kobayashi等人于《血液》杂志上发表了一篇新研究，其发现NK细胞在侵袭性B细胞淋巴瘤中经历了大量的转录重编程，并伴有脂质代谢增强，包括转录调节因子PPAR-g的表达水平升高。

暴露于淋巴瘤环境中的脂肪酸可显著抑制NK细胞效应反应和细胞代谢。从弥漫大B细胞淋巴瘤患者和Eμ-myc -B细胞淋巴瘤小鼠中分离的NK细胞的IFN-g产量均减少。激活PPAR-g部分恢复了线粒体的膜电位和IFN-g的产生。

综上所述，本研究表明，增强脂质代谢，同时损害其功能，是NK细胞对富含脂肪酸的淋巴瘤环境的功能适应。

原始出处：

Takumi Kobayashi,et al. Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood. August 20,2020.

评论区 (13)
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    2020-10-27 147769bbm19暂无昵称

    太棒了！

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=894859, encodeId=a282894859ac, content=太棒了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b7925218974, createdName=147769bbm19暂无昵称, createdTime=Tue Oct 27 15:59:04 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892564, encodeId=99b189256482, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201002/21504fa67751486f8b362fadffbc2c91/c092c62a4c4e43aca6edd018dacc3733.jpg, createdBy=6e855412268, createdName=., createdTime=Fri Oct 16 23:15:29 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886710, encodeId=906b886e1039, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0c9a2254373, createdName=1216f9c2m26暂无昵称, createdTime=Sat Sep 19 21:07:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885726, encodeId=dc42885e2666, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f9f4936978, createdName=805630214, createdTime=Wed Sep 16 11:31:21 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883820, encodeId=41088838203a, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200824/adf7aecfa5784daea5f08c970b83d994/0c12e9fb19ae40d08386eb25dc4582a2.jpg, createdBy=61c72495945, createdName=金牛♉, createdTime=Wed Sep 09 11:00:56 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882595, encodeId=887488259544, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/hVlZydg15H9RbCGhvDX3I1gh2v2BgDDrf5qMLtgUHxVlkiakiaLiaxNXf1KzPQw6JHhlFCtYVyakhOMqOI53q2cnA/132, createdBy=2e745191043, createdName=陈东, createdTime=Thu Sep 03 23:39:56 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353400, encodeId=8a7d135340099, content=<a href='/topic/show?id=c4d484423fa' target=_blank style='color:#2F92EE;'>#脂质代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84423, encryptionId=c4d484423fa, topicName=脂质代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Sep 03 14:02:58 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882328, encodeId=690288232819, content=阅读谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Sep 03 06:40:04 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882183, encodeId=c9f6882183e2, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=626e1296645, createdName=573722703, createdTime=Wed Sep 02 13:11:11 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882159, encodeId=81598821599c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=efb05136804, createdName=14669b93m32暂无昵称, createdTime=Wed Sep 02 11:12:48 CST 2020, time=2020-09-02, status=1, ipAttribution=)]
    2020-10-16 .

    👍

    0

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    2020-09-19 1216f9c2m26暂无昵称

    学习

    0

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    2020-09-16 805630214

    谢谢分享，学习了

    0

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    2020-09-09 金牛♉

    很棒

    0

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    2020-09-03 陈东

    学习

    0

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    2020-09-03 zhaojie88

    #脂质代谢#

    0

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    2020-09-03 刘煜

    阅读谢谢分享

    0

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    2020-09-02 573722703

    哦

    0

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    2020-09-02 14669b93m32暂无昵称

    学习

    0

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