Diabetes Care:儿童胰腺炎与成年后糖尿病风险

2019-11-07 xing.T MedSci原创

由此可见,青春期晚期胰腺功能正常但儿童期存在急性胰腺炎病史是发生2型糖尿病的危险因素,尤其是在年轻成人中。

急性胰腺炎与糖尿病的关系尚不清楚。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估已治愈的儿童期急性胰腺炎单次事件是否与成年期糖尿病的发生有关。

该研究是基于全国的人群研究,分析了1802110名以色列青少年(平均年龄17.4岁[年龄范围为16-20岁]),这些受试者在1979年至2008年期间进行义务兵役之前进行了检查,其数据与以色列国家糖尿病登记中心链接。已治愈的胰腺炎定义为入组时具有正常胰腺功能的急性胰腺炎的单次事件史。结果通过回归分析进行比较。

已治愈的胰腺炎的受试者中有4.6%的患者发生了糖尿病(281例中有13例;这些病例中没有一例被确定为1型糖尿病),未暴露的人群中发生糖尿病占2.5%(1801716例中有44463例)。已治愈的急性胰腺炎与偶发性糖尿病相关,比值比(OR)为2.23(95%CI为1.25–3.98),并调整了年龄、性别和出生年份。在对基线BMI和社会人口统计学混杂因素作进一步调整后,结果仍然存在(OR为2.10[95%CI为1.15–3.84])。儿童胰腺炎与年轻时的糖尿病诊断有关,其中92%的糖尿病病例在40岁之前被诊断出,而未暴露组则为47%(P=0.002)。当研究样本仅限于健康状况不佳或基线BMI正常的个体时,这种关联性加强。

由此可见,青春期晚期胰腺功能正常但儿童期存在急性胰腺炎病史是发生2型糖尿病的危险因素,尤其是在年轻成人中。 

原始出处:

Cole D. Bendor,et al.Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.Diabetes Care.2019.https://doi.org/10.2337/dc19-1562

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    2019-11-08 misszhang

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    2019-11-07 一个字-牛

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