Diabetes Res Clin Pract:严重低血糖是糖尿病肾病的独立危险

2015-05-31 沐晴 MedSci原创

目的:研究认为低血糖与糖尿病微血管病变相关,因此本研究能够旨在评估严重低血糖在2型糖尿病肾功能不全的影响。 <span style="font-size:10.5pt;mso-bidi-font-family: Helvetica;color:#2F2F33;text-transform:uppercase;font-weight:normal">方法:研究选择在一家大型的三级医院,选择2

目的:研究认为低血糖与糖尿病微血管病变相关,因此本研究能够旨在评估严重低血糖在2型糖尿病肾功能不全的影响。

方法:研究选择在一家大型的三级医院,选择2004年-2013年间的门诊病例进行回顾性队列研究。一共筛选出101名2型糖尿病门诊患者入组,这些患者既往均发生过严重低血糖。另筛选101名2型糖尿病,无低血糖病史患者作为对照,对照组患者的血肌酐、年龄、性别、糖尿病病程作为对照基线。

结果:在合并低血糖和严重低血糖组,血肌酐水平(1.42±0.75mg/dL)显著的增加至1.77±1.26和 1.93±1.54mg/dL,基础eGFR(44.37±26.13ml/min/1.73m2下降至41.28±27.70和37.64±24.54ml/min/1.73 m2;然而在未合并低血糖组未观察到这种差异。

多元线性回归分析显示,严重低血糖对所有2型糖尿病来说,都是血肌酐水平上升和eGFR下降的独立危险因素;而且,在存在严重低血糖的T2DM组,基础肌酐水平、糖尿病病史长、低HbA1c,都是加剧肾损害的危险因素。

结论:严重低血糖与糖尿病肾病患者的肾功能恶化显著相关,基础肌酐水平高、糖尿病病史长的患者更容易加剧出现肾功能不全。

原始出处:


Lee YL1, Chen BK2, Lin KD1, Su RW3, Lee MY1, Hsiao PJ4, Shin SJ5.The impact of severe hypoglycemia on renal impairment in type 2 diabetes.Diabetes Res Clin Pract. 2015 Jun;108(3):448-55. doi: 10.1016/j.diabres.2015.02.028. Epub 2015 Mar 3.

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    2015-07-29 sundong

    严重低血糖又该如何判断呢

    0

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    2015-06-25 nizongzan

    高低都不好

    0

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    2015-06-25 nizongzan

    好不好?

    0

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    2015-06-09 ljjj1053

    认真学习了

    0

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