Hypertension:颈总动脉直径与心血管事件和死亡风险!

2018-05-21 xing.T MedSci原创

由此可见,该研究发现了较大的颈动脉直径与卒中、CVD和死亡相关。颈动脉内膜中层厚度是血压相关中才能增厚的一个指标,部分解释了与卒中发病率的关系。

颈动脉直径增大是动脉重塑的一种表现,可能是心血管疾病(CVD)的危险因素。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估了颈动脉直径与卒中、冠心病、心血管疾病和全因死亡风险之间的联系,并探讨了这些关联是否可以通过动脉重塑的过程来解释,即血压相关中层增厚、动脉硬化、动脉壁应力和动脉粥样硬化。

研究人员从4个队列研究(鹿特丹研究、NEPHROTEST研究、Hoorn研究和Braser-等人的研究)中纳入了4887名参与者(平均年龄为67±9岁;54%女性)。研究人员采用回声跟踪法测量颈总动脉的特性。根据医疗记录记录事故病例。研究人员使用Cox比例风险模型调整心血管危险因素和估计潜在的动脉重塑过程。

随访期间(平均随访11年),379例(8%)患者发生卒中,516例(11%)患者发生冠心病,807例(17%)患者出现CVD,1486例(30%)患者死亡。调整心血管危险因素后,颈动脉直径最高三分位数(直径>8 mm)的个体与最低三分位数(直径<7 mm)个体相比,卒中发生率较高(风险比为1.5,95%可信区间为1.1-2)。根据动脉重建过程的所有估计,调整颈动脉内膜-中层厚度可减弱这种关联(调整内膜-中膜厚度后的风险比为1.2;95%可信区间为0.9-1.6)。颈动脉直径较大与心血管疾病和死亡风险相关,但与冠心病风险无关。

由此可见,该研究发现了较大的颈动脉直径与卒中、CVD和死亡相关。颈动脉内膜中层厚度是血压相关中才能增厚的一个指标,部分解释了与卒中发病率的关系。

原始出处:

Sanaz Sedaghat,et al. Common Carotid Artery Diameter and Risk of Cardiovascular Events and Mortality Pooled Analyses of Four Cohort Studies.Hypertension.2018. https://doi.org/10.1161/HYPERTENSIONAHA.118.11253

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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
  6. 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 23 06:49:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317529, encodeId=fa4731e52998, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AicRibibwhnWAW33YRia7y5sicGOoEzFQ4Jzmt3N9mtq1lZOXghRysQ33pzibKOXyQUuTpZSGsEeyicy1zX75nRB1yuaQ/132, createdBy=5e942360447, createdName=foxv3羽翼, createdTime=Tue May 22 12:25:40 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317400, encodeId=c93231e40044, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-23 大爰

    学习了谢谢分享!!

    0

  7. 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 23 06:49:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317529, encodeId=fa4731e52998, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AicRibibwhnWAW33YRia7y5sicGOoEzFQ4Jzmt3N9mtq1lZOXghRysQ33pzibKOXyQUuTpZSGsEeyicy1zX75nRB1yuaQ/132, createdBy=5e942360447, createdName=foxv3羽翼, createdTime=Tue May 22 12:25:40 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317400, encodeId=c93231e40044, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-22 foxv3羽翼

    谢谢分享.学习了

    0

  8. 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createdBy=f99523187183, createdName=hukaixun, createdTime=Thu May 31 06:29:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038902, encodeId=519d2038902fe, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sat Dec 15 10:29:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255763, encodeId=31fd1255e6373, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 23 06:49:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317529, encodeId=fa4731e52998, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AicRibibwhnWAW33YRia7y5sicGOoEzFQ4Jzmt3N9mtq1lZOXghRysQ33pzibKOXyQUuTpZSGsEeyicy1zX75nRB1yuaQ/132, createdBy=5e942360447, createdName=foxv3羽翼, createdTime=Tue May 22 12:25:40 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317400, encodeId=c93231e40044, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-22 张新亮1853311252142e2fm

    好文献学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1727310, encodeId=daac1e27310f0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 06 11:29:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643539, encodeId=8c001643539f3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 23 06:49:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317529, encodeId=fa4731e52998, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AicRibibwhnWAW33YRia7y5sicGOoEzFQ4Jzmt3N9mtq1lZOXghRysQ33pzibKOXyQUuTpZSGsEeyicy1zX75nRB1yuaQ/132, createdBy=5e942360447, createdName=foxv3羽翼, createdTime=Tue May 22 12:25:40 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317400, encodeId=c93231e40044, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 131****2916

    不错的文章值得推荐一下了.

    0

  10. 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 23 06:49:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317529, encodeId=fa4731e52998, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AicRibibwhnWAW33YRia7y5sicGOoEzFQ4Jzmt3N9mtq1lZOXghRysQ33pzibKOXyQUuTpZSGsEeyicy1zX75nRB1yuaQ/132, createdBy=5e942360447, createdName=foxv3羽翼, createdTime=Tue May 22 12:25:40 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317400, encodeId=c93231e40044, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Tue May 22 07:00:28 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317322, encodeId=80c231e322e1, content=不错的文章值得推荐一下了., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 21 22:53:52 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317311, encodeId=1f7031e31151, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 21 22:36:16 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0