J Periodontol:香烟、电子烟和非吸烟者种植体周促炎细胞因子水平和临床参数的差异

2018-10-16 MedSci MedSci原创

吸烟会影响牙种植体治疗的预后,并且与种植体周围骨丢失和种植失败率的风险增加有关。目前缺乏对比吸烟者(CS),电子香烟(e-cigs)和非吸烟者(NS)的临床、放射学和植体周围免疫的研究数据。这项研究旨在比较CS、e-cigs和NS的种植体周临床和放射学参数以及基质金属蛋白酶(MMP)-9和白细胞介素(IL)-1β的水平。 研究纳入了32个CS(第1组),31个e-cigs(第2组)和32个N

吸烟会影响牙种植体治疗的预后,并且与种植体周围骨丢失和种植失败率的风险增加有关。目前缺乏对比吸烟者(CS),电子香烟(e-cigs)和非吸烟者(NS)的临床、放射学和植体周围免疫的研究数据。这项研究旨在比较CS、e-cigs和NS的种植体周临床和放射学参数以及基质金属蛋白酶(MMP)-9和白细胞介素(IL)-1β的水平。

研究纳入了32个CS(第1组),31个e-cigs(第2组)和32个NS(第3组)。使用结构化基线调查表收集人口统计学和植入相关数据。记录种植体周菌斑指数(PI),探诊出血(BOP)和探诊深度(PD),并使用标准化数字X射线照片评估边缘骨丢失(MBL)。酶联免疫吸附试验用于评估种植体周围龈沟液中MMP-9和IL-1β的水平。 Pearson相关系数用于分析MMP-9和IL-1β水平与种植体周围参数的相关性。

结果显示,与第1组和第2组相比,BOP在组3中显示出明显更高的值(p <0.01)。PI组(p <0.01),PD≥4mm(p <0.01)和MMP-9(p <0.001)和IL-1β(p <0.01)的平均浓度在组1和组2中明显高于组3。与第2组和第3组相比,第1组的MBL明显更高(p <0.01)。 MMP-9(p = 0.0198)和IL-1β(p = 0.0047)水平与第1组MBL之间存在明显正相关;第2组IL-1β与MBL呈明显正相关(p = 0.0031)。

综上所述,该研究结果表明,与e-cigs和NS相比,CS者更容易出现围手术期炎症。CS和e-cigs中促炎细胞因子水平的增加表明可能更大的种植体周围炎症反应。

原始出处:

ArRejaie AS, Al-Aali KA, et al., Proinflammatory cytokine levels and peri-implant parameters among cigarette smokers, individuals vaping electronic cigarettes and non-smokers. J Periodontol. 2018 Oct 12. doi: 10.1002/JPER.18-0045.  

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    2019-01-21 feather89
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time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343831, encodeId=81a3134383143, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Oct 18 06:04:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372865, encodeId=603a13e2865d6, content=<a href='/topic/show?id=63ff1014107e' target=_blank style='color:#2F92EE;'>#香烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1809575, encodeId=d37818095e522, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Thu Oct 25 10:04:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924582, encodeId=28961924582eb, content=<a href='/topic/show?id=a48de78481b' target=_blank style='color:#2F92EE;'>#细胞因子水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77848, encryptionId=a48de78481b, 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time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343831, encodeId=81a3134383143, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Oct 18 06:04:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372865, encodeId=603a13e2865d6, content=<a href='/topic/show?id=63ff1014107e' target=_blank style='color:#2F92EE;'>#香烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101410, encryptionId=63ff1014107e, topicName=香烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Thu Oct 18 06:04:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605129, encodeId=8a6716051296a, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Thu Oct 18 06:04:00 CST 2018, time=2018-10-18, status=1, ipAttribution=)]
    2018-10-30 huangdf
  6. 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time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343831, encodeId=81a3134383143, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Oct 18 06:04:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372865, encodeId=603a13e2865d6, content=<a href='/topic/show?id=63ff1014107e' target=_blank style='color:#2F92EE;'>#香烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, 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  7. 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