Nat Med:首次证实人神经干细胞移植可改善脊髓损伤猴子的抓力

2018-04-03 佚名 “细胞”微信号

在一项新的研究中,研究人员报道移植到猴子受损脊髓中的人神经干细胞成熟为神经元,触发神经连接形成,从而让这些猴子抓住橙子的能力得到改善。相关研究结果近期发表在Nature Medicine期刊上,论文标题为“Restorative effects of human neural stem cell grafts on the primate spinal cord”。

在一项新的研究中,研究人员报道移植到猴子受损脊髓中的人神经干细胞成熟为神经元,触发神经连接形成,从而让这些猴子抓住橙子的能力得到改善。相关研究结果近期发表在Nature Medicine期刊上,论文标题为“Restorative effects of human neural stem cell grafts on the primate spinal cord”。

在这项研究中,Tuszynski和他的同事们切掉猕猴的一段脊髓,然后在两周后将人神经祖细胞(neural progenitor cell)移植到这种脊髓损伤部位。在首批4只猴子中,这些细胞移植物没有保持在原位,这一发现迫使这些研究人员将更多的纤维蛋白原-凝血酶(fibrinogen–thrombin)添加到这些细胞移植物中。纤维蛋白原-凝血酶是一种蛋白-酶混合物,可让这些移植物更快地附着到损伤位点上。Tuszynski团队还不得不让手术台倾斜以便排出脑脊液,这是因为脑脊液会将这些移植物冲走。

经过这些调整后,在剩余的5只猴子中,这些移植的神经干细胞保留在原位,而且这些研究人员观察到这些移植的干细胞发育成神经元和神经胶质细胞。在损伤部位中,这些人神经元产生高达15万个线状轴突,这些轴突从移植位点处向外延伸高达50毫米,并且早在这些新产生的神经细胞就位两个月后,这些研究人员就能够观察到它们与猴子本身的神经细胞建立神经连接。在大多数情况下,细胞移植物附着在脊髓损伤部位的猴子能够更好地操纵它们的手指,使它们的手指绕着橙子弯曲,而细胞移植物未附着的猴子并不能握住橙子,它们的手指保持折叠,因此橙子停留在它们的指关节上。

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    2019-01-26 liye789132251
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  5. 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createdBy=bc7215920711, createdName=bsmagic9137, createdTime=Thu Apr 05 04:25:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608714, encodeId=596a1608e14b2, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Apr 05 04:25:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302376, encodeId=56cb3023e626, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Apr 03 13:31:14 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-07 chenfeixian

    讲的非常好!

    0

  6. 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  7. 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  8. 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style='color:#2F92EE;'>#猴子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68226, encryptionId=0a8f68226b7, topicName=猴子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=735537811831, createdName=ms1948154235210413, createdTime=Sat Oct 13 14:25:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303625, encodeId=dedc303625de, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce432028753, createdName=chenfeixian, createdTime=Sat Apr 07 18:55:56 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397508, encodeId=09a6139e508f1, content=<a href='/topic/show?id=8bee565436d' target=_blank 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  9. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Apr 03 13:31:14 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-03 sunfeifeiyang

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