Lancet Psychiat:围产期抑郁症的临床表型与症状发作时间

2017-05-03 zhangfan MedSci原创

在整个怀孕和产后可能有不同类型和严重程度的围产期抑郁症,临床上需要依据患者情况定制的治疗方案改善围产期抑郁症

围产期是一个抑郁症发病的高风险的时间,与许多抑郁症发病率和死亡率包括产妇自杀相关。围产期抑郁症是特异性性的临床亚型,需要进一步完善疾病认识以改善治疗结果。近日研究人员就围产期抑郁症临床相关表型亚型进行识别和描述,进一步分析了怀孕期间和产后三个时期的亚型特点。

研究人员从19个国际产后抑郁症站点收集了19至40岁的妇女围产期抑郁症状发生的相关信息,进行爱丁堡产后抑郁(EPDS)评分并将国家心理健康研究领域的标准研究(RDOC)负效价和唤醒功能与EPDS一起来反映孕产妇心情郁闷,焦虑和压抑状态。

研究共分析了663名妇女数据,通过EPDS发现了三个可衡量的基本特征:心情压抑、焦虑、压抑,进一步研究人员确定了五个不同的亚型的围产期抑郁症:严重的焦虑抑郁症,中度焦虑抑郁、快感缺失型焦虑,快感缺失,解决抑郁症。这些亚型在症状程度和发病时间上有明显差异,焦虑和快感缺失成为主要症状,在产后发病通常比较严重。

研究结果表明,在整个怀孕和产后可能有不同类型和严重程度的围产期抑郁症,临床上需要依据患者情况定制的治疗方案改善围产期抑郁症。

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    2018-04-09 howi
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Thu May 04 07:43:20 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193573, encodeId=63221935e31d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu May 04 07:39:00 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193557, encodeId=300319355e54, content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, 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  5. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 tastas
  6. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 医艺依意

    学习了,谢谢分享

    0

  7. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 榄枷檬

    谢谢分享

    0

  8. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 七堇

    抑郁症要及早诊治预防。后遗无穷。

    0

  9. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 深海的鱼

    这是个高风险的时刻

    0

  10. 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content=抑郁症要及早诊治预防。后遗无穷。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Thu May 04 07:24:48 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193532, encodeId=128e19353273, content=这是个高风险的时刻, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu May 04 07:00:15 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193530, encodeId=c01f193530db, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Thu May 04 06:52:04 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 Drhzm308

    不错,学习了

    0

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Lancet:从青春期和怀孕前期预测围产期抑郁症

背景:围产期抑郁症是一种被忽视的全球性健康问题,影响高收入国家的10-15%的女性和低收入国家较大比例的女性。对孩子的影响有认知,行为和情感困难,并且围产期抑郁症与发育迟缓和身体疾病有关。在维多利亚代际健康队列研究(VIHCS)中,研究人员的目的是评估在怀孕前有心理健康问题历史的女性围产期抑郁症状的程度。    方法:VIHCS研究室是对维多利亚青少年健康队列研究(V