Hypertension:无论血压水平,接受降压药物治疗的患者内皮功能受损!

2017-08-15 xing.T MedSci原创

由此可见,无论高血压患者通过降压药物治疗血压达到何种水平,FMD评估的内皮功能都会受到损害。

高血压与内皮功能障碍有关,在没有服用降压药的受试者中血压与内皮功能显著相关。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在确定治疗状态是否会影响血压与血管内皮功能之间的关系。

研究人员测量了2297名受试者的血流介导的血管舒张功能(FMD),其中包括1822名未进行抗高血压药物治疗的患者和475名抗高血压治疗患者。

研究人员发现FMD显著降低与收缩压增加相关(收缩压小于120mmHg的受试者为8.2±3.1%,120-129mmHg为7.5±2.8%,130-139mmHg为7.1±2.8%,大于140mmHg为6.7±2.6%;P<0.001)。在未经治疗的患者中,收缩压与FMD独立相关。与此相反,在接受治疗的高血压患者中,收缩压与FMD没有显著关系(收缩压小于120mmHg的接受治疗的受试者为4.6±3.1%,120-129mmHg为4.8±2.7%,130-139mmHg为4.9±2.8%,大于140mmHg为4.5±2.3%;;P=0.77)。

由此可见,无论高血压患者通过降压药物治疗血压达到何种水平,FMD评估的内皮功能都会受到损害。

原始出处:

Tatsuya Maruhashi,,et al. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level FMD-J Study (Flow-Mediated Dilation Japan).Hypertension.2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09612

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    2017-08-18 feather89
  4. 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    2017-08-17 海之蓝

    学习

    0

  5. 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  6. 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  7. 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  8. 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    2017-08-16 龙胆草

    学习谢谢分享

    0

  9. 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    2017-08-15 有备才能无患

    无论高血压患者通过降压药物治疗血压达到何种水平,FMD评估的内皮功能都会受到损害。

    0

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