J Rheumatol:系统性硬化症中手指溃疡临床评估评分的初步验证

2018-11-22 xiangting MedSci原创

该研究初步建议DUCAS作为SSc相关性DU的新临床评分,DUCAS具有表面和内容的有效性以及聚合/发散相关性(结构有效性)。

截至目前,"愈合/未愈合"和临床判断是系统性硬化症(SSc)患者手指溃疡(DU)的唯一可用评估工具。这项研究目的是检查SSc初步综合DU临床评估评分(DUCAS)表面、内容和结构的有效性。

纳入至少1个手指出现DU的SSc患者,并使用健康评估问卷-残疾指数、Cochin量表、DU相关疼痛的视觉模拟量表(VAS)、患者整体DU状态、整体评估作为患者报告结局(PRO)以及作为SSc-DU专业医师/护士指标的DU状态医师VAS(phyGDU)进行评估。DUCAS包括由SSc DU专家委员会选择的7个DU相关变量,并在临床基础上进行加权。通过达成共识分析表面的有效性。并使用Spearman相关性,通过与其他手部功能指标的集合相关性来测试部分结构的有效性。检查了一系列的SSc患者。使用反向逐步分析的线性回归模型来确定个体变量与主要临床参数phyGDU的关联。

研究共招募了44名SSc患者(9名男性,平均年龄55±15岁,平均病程9.9±5.8年)。总体DUCAS与所有上述PRO存在显著正相关(r>0.4,p<0.01)。当对所有评分和量表进行建模时,只有DUCAS可以显著预测phyGDU(r=0.59,R2=0.354,AIC信息准则=385.4)。

该研究初步建议DUCAS作为SSc相关性DU的新临床评分,DUCAS具有表面和内容的有效性以及聚合/发散相关性(结构有效性)。这些早期数据表明该评分值得进一步的评估。

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