Prostate Cancer P D:YAP1的表达在高等级前列腺癌中增加而在神经内分泌前列腺癌中减少

2020-05-10 AlexYang MedSci原创

在进行长期的雄激素阻断治疗后,25%到30%的前列腺癌(PCa)会恶化成为侵袭性神经内分泌(NE)表型。YAP1是Hippo途径的一个转录共激活子,其异常的调控已经表明与癌症的恶化有关。然而,其在神经

在进行长期的雄激素阻断治疗后,25%到30%的前列腺癌(PCa)会恶化成为侵袭性神经内分泌(NE)表型。YAP1是Hippo途径的一个转录共激活子,其异常的调控已经表明与癌症的恶化有关。然而,其在神经内分泌前列腺癌(NEPC)中的作用还未有评估。

研究人员使用了免疫组化和生物信息学分析评估了PCa起始和进展期间YAP1的表达水平。研究发现,YAP1的表达在良性前列腺组织的基底上皮细胞中存在,而在低等级PCa中缺失,但是在高等级前列腺癌中表达提高。有趣的是,YAP1的表达在人类和小鼠NEPC中菌减少或者丧失。

最后,研究人员指出,YAP1的表达在高等级前列腺癌中提高,而在NEPC中丧失。

原始出处:

Siyuan Cheng, Nestor Prieto-Dominguez, Shu Yang et al. The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer. Prostate Cancer P D. 20 April 2020

 

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    2020-07-08 xinmeili
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    2021-01-18 gujh
  6. [GetPortalCommentsPageByObjectIdResponse(id=1682608, encodeId=3ecb16826084f, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Nov 13 00:52:32 CST 2020, time=2020-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791616, encodeId=f2c31e91616ae, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu Nov 05 14:52:32 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715757, encodeId=1b8a1e15757b8, content=<a href='/topic/show?id=24051893e0f' target=_blank style='color:#2F92EE;'>#YAP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18937, encryptionId=24051893e0f, topicName=YAP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941632034462, createdName=xinmeili, createdTime=Wed Jul 08 15:52:32 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953770, encodeId=81b81953e703c, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sat Nov 14 04:52:32 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081917, encodeId=a33d208191e94, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Mon Jan 18 04:52:32 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364596, encodeId=5684136459638, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue May 12 02:52:32 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602268, encodeId=0a6b16022686e, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue May 12 02:52:32 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040741, encodeId=8bb11040e414c, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun May 10 14:52:32 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
    2020-05-12 lsndxfj
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    2020-05-12 sunylz
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    2020-05-10 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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专注于研发前列腺癌新疗法的制药公司ESSA今日宣布,美国FDA允许ESSA继续进行EPI-7386的临床研究,以治疗转移性去势抵抗性前列腺癌(mCRPC)。

Clin Cancer Res:基因组不稳定性是侵袭性前列腺癌的区别性特征

侵袭性变体前列腺癌(AVPC)代表着一种临床亚型,可以通过治疗抗性和不良预后区分,并且与肿瘤抑制基因(TSG)PETN、RB1和TP53丧失有关。循环肿瘤细胞(CTC)为AVPC的最小侵入性鉴定和分子

N Engl J Med:奥拉帕尼治疗转移去势抵抗性前列腺癌研究

在前列腺癌和其他癌症患者中,与DNA修复(包括同源重组修复)有关基因的多个基因功能丧失变异与聚(二磷酸腺苷-核糖)聚合酶(PARP)抑制剂响应相关。

Eur Urol:前列腺癌中的标准化和简化机器人辅助超扩展盆腔淋巴结清扫术

在经历根治性前列腺切除术(RP)的中等风险和高风险前列腺癌(PCa)患者中,扩展盆腔淋巴结清扫术(ePLND)仍旧是淋巴结分期最准确的方法。而在非常高风险PCa患者中可以考虑使用超扩展盆腔淋巴结清扫术

Zydus Cadila推出恩杂鲁胺液体胶囊Obnyx,将使该前列腺癌疗法的价格降低2/3

Obnyx的推出可将治疗费用显着降低近70%,其每周治疗费用为5995卢比,每月治疗费用低于27000卢比。

Eur Urol:恩杂鲁胺雄激素阻断治疗联用对转移激素敏感性前列腺癌患者健康相关生活质量影响研究

ARCHES研究中的转移激素敏感性前列腺癌(mHSPC)中,与单独的ADT治疗相比,恩杂鲁胺与雄激素阻断治疗(ADT)联用能够改善影像学无进展生存(rPFS)。最近,有研究人员评估了长达73周的患者报