J Endod:根尖周“炎症栓塞”在牙髓再生中的影响:一项组织学研究

2019-12-27 lishiting MedSci原创

这篇研究的目的是为了评估根尖“炎症栓塞”-一种炎症占据根尖孔的现象对根管治疗再生潜力的影响。

这篇研究的目的是为了评估根尖"炎症栓塞"-一种炎症占据根尖孔的现象对根管治疗再生潜力的影响。

研究对12个犬牙齿的根管实施了根管治疗(RCT),机械清创、根尖预备至0.5-mm宽,并采用以下材料实施根管封闭:胶原海绵、富含血小板的纤维蛋白和血凝块(未采用任何材料)。

结果显示,在12例RCTs中,研究成功的保持了8个根管根尖周组织的完整性。在余下的4例4 RCTs中尖周组织受到损伤,进而引发感染并造成骨和牙本质的吸收。组织学分析显示,炎症栓塞中含有大量的M1巨噬细胞,这与根管内无细胞浸润有关。相反,无感染样本中出现修复的迹象,可见尖周细胞向根管内迁移。

结论:试图获得牙髓再生的过程中,尖周感染的控制是治疗成功的关键。

原始出处:

Zaky SH, AlQahtani Q, et al. Effect of the Periapical "Inflammatory Plug" on Dental Pulp Regeneration: A Histologic In Vivo Study. J Endod. 2020 Jan;46(1):51-56. doi: 10.1016/j.joen.2019.10.006.

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