BMJ:米氮平联合SSRI或SNRIs治疗难治性抑郁症

2018-11-01 zhangfan MedSci原创

研究不支持在SNRI或SSRI治疗基础上增加米氮平用于难治性原发性抑郁患者

近日研究人员考察了米氮平联合5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)或选择性5-羟色胺再摄取抑制剂(SSRI)治疗原发性抑郁症的疗效。

本次研究为III期临床研究,在英国开展。480名Beck抑郁量表评分14分以上的成年患者参与研究,患者接受SSRI 或SNRI治疗6周以上但抑郁症状未显著改善,其中241人在原有治疗方案基础上增加米氮平,239人服用安慰剂,研究的主要终点为12周Beck抑郁量表评分。次要终点包括焦虑、生活质量以及不良事件。

研究发现,米氮平组12周抑郁量表评分较对照组有所下降,但不显著(18.0 vs 19.7分,差异仅为1.83),并且服用米氮平的患者不良事件以及停药率均显著增加。

研究不支持在SNRI或SSRI治疗基础上增加米氮平用于难治性原发性抑郁患者。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
    2018-12-13 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
    2018-12-21 13718711b3m

    值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]
    2018-11-03 freve
  7. [GetPortalCommentsPageByObjectIdResponse(id=1848632, encodeId=2aca18486325a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 13 04:55:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955133, encodeId=4de01955133a8, content=<a href='/topic/show?id=d9db98635ef' target=_blank style='color:#2F92EE;'>#难治性抑郁症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98635, encryptionId=d9db98635ef, topicName=难治性抑郁症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Wed Mar 20 02:55:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356051, encodeId=e425356051c5, content=值得借鉴与学习的临床经验,涨知识,获益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Dec 21 23:42:39 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956422, encodeId=a1241956422f9, content=<a href='/topic/show?id=1b2916500af' target=_blank style='color:#2F92EE;'>#SNRIs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16500, encryptionId=1b2916500af, topicName=SNRIs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sun Jun 30 09:55:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445752, encodeId=beab1445e52a3, content=<a href='/topic/show?id=7da8e61022e' target=_blank style='color:#2F92EE;'>#米氮平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76102, encryptionId=7da8e61022e, topicName=米氮平)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=QsAdw9VPoRJYYKsEgQr5iag&s=100&t=1556575911, createdBy=c7cd5178211, createdName=lifestar, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528525, encodeId=75cd152852582, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545472, encodeId=e89515454e2d3, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sat Nov 03 00:55:00 CST 2018, time=2018-11-03, status=1, ipAttribution=)]

相关资讯

米氮平导致乳溢发生一例

主诉:患者女性,34岁,已婚,生1子,月经正常,非哺乳期。因少语、少动、忧愁3个月余于2011年1月10日就诊。自述3个月前与家人生气后出现失眠、少语、忧愁,之后进展为整日情绪低落,对任何事情均无兴趣,有生不如死感,未治疗。 既往史:体健,无其他重大疾病史及家族病史。 精神检查:意识清晰,未引出感知觉障碍;思维缓慢,未引出幻觉、妄想症状,情绪低落,意志活动减退,无自知力。体格检查未见异常。

APA:米氮平在抑郁症治疗中的作用

      米氮平是第一个去甲肾上腺素( NE)能和特异性5一羟色胺(5-HT)能抗抑郁药(NaSSA),美国精神病学学会(American Psychiatric  Associalion)于2010年10月正式发布的第3版《抑郁症治疗指南》(以下简称《2010版指南》)中,将米氮平推荐为不同抑郁症治疗阶段以及多种特殊人群的治