ADV FUNCT MATER:多功能纳米诊疗平台,双模态成像导航下的肿瘤联合治疗

2017-05-30 佚名 MaterialsViews

近年来,得益于纳米技术、分子影像、肿瘤生物学等学科的飞速发展,纳米医学这一新兴交叉学科得到了长足的进步。鉴于其在前期试验阶段所展现出的良好治疗效果,越来越多的人认为纳米医学将在人类与癌症等疑难疾病的抗争中发挥着不可忽视的重要作用。目前,开发多功能诊疗一体化纳米平台,实现治疗过程的可视化、个体化以及精准化,已成为这一领域的重要发展方向,并将会对有效降低治疗的毒副作用并最终实现对肿瘤的高效杀灭产生深远

近年来,得益于纳米技术、分子影像、肿瘤生物学等学科的飞速发展,纳米医学这一新兴交叉学科得到了长足的进步。鉴于其在前期试验阶段所展现出的良好治疗效果,越来越多的人认为纳米医学将在人类与癌症等疑难疾病的抗争中发挥着不可忽视的重要作用。目前,开发多功能诊疗一体化纳米平台,实现治疗过程的可视化、个体化以及精准化,已成为这一领域的重要发展方向,并将会对有效降低治疗的毒副作用并最终实现对肿瘤的高效杀灭产生深远的意义。

最近,澳门大学陈美婉教授课题组和苏州大学刘庄教授课题组合作,在新型肿瘤诊疗一体化纳米平台构建方面取得了重要进展。研究人员将亲水性顺铂前药与疏水性磷脂分子共价偶联,制备了两亲性磷脂化顺铂前药分子(Pt(IV)-DSPE),并将Pt(IV)-DSPE作为基本的结构单元与其他磷脂分子通过自组装的方法制备成脂质体(Pt(IV)-liposome),发现其载药量连续可调、药物包封率高达92.9%、并且具有长时间体内循环行为。同时,利用脂质体良好的分子装载能力,研究人员将一种疏水性近红外荧光染料分子(DiR)装载到脂质体的磷脂双分子层内;利用DiR的近红外荧光信号和光声信号实现了对DiR-Pt(IV)-liposome体内行为的实时监控,发现了DiR-Pt(IV)-liposome具有超高的肿瘤富集效果。此外,利用DiR分子的光热效应,研究人员发现DiR-Pt(IV)-liposome与光热治疗联合使用可以有效的抑制肿瘤的生长,而相同剂量下单独的化疗或光热治疗都无法有效抑制肿瘤的生长,表明了联合治疗在高效杀灭肿瘤方面具有明显的优势。

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    2017-05-31 1deac927m81(暂无匿称)

    很好,学习了。

    0

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    2017-05-31 飛歌

    学习了很有用

    0

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    2017-05-30 solarjin

    感谢梅斯医学,受教了

    0

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    2017-05-30 laymankey

    感谢分享一下!

    0

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    2017-05-30 林3301

    不错,学习了

    0

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    2017-05-30 明月清辉

    谢谢分享,学习了

    0

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    2017-05-30 有备才能无患

    利用DiR分子的光热效应,研究人员发现DiR-Pt(IV)-liposome与光热治疗联合使用可以有效的抑制肿瘤的生长,而相同剂量下单独的化疗或光热治疗都无法有效抑制肿瘤的生长,表明了联合治疗在高效杀灭肿瘤方面具有明显的优势。

    0

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    2017-05-30 ann y

    血管化组织再生新思路——把生物诱发信号引入3D生物打印

    0