J Thromb Haemost:首次心肌梗死住院后静脉血栓栓塞的合并症和风险

2020-04-22 MedSci原创 MedSci原创

与一般人群相比,MI后30天VTE风险显著增加。尽管VTE绝对风险较低,但合并症却大大增加了这种风险,尤其是偏瘫和癌症。在这类高危患者中可能需要预防VTE,但需要进一步研究。

心肌梗死(MI)是静脉血栓栓塞(VTE)的危险因素。虽然合并症会影响MI的预后,但尚不清楚它们是否会影响MI后的VTE风险。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在评估合并症对MI后VTE风险的影响。

研究人员使用全国性的人口登记系统确定了在丹麦(1995-2013年)发生的因MI首次住院以及随后发生VTE的患者。研究人员根据MI患者性别、年龄和合并症按5:1比例与一般人群进行匹配组建了对照队列,并计算了30天和1-12个月的VTE累积风险、发生率和风险比。研究人员还通过计算相互作用对比和与相互作用有关的归因分数,评估了MI和合并症之间的相互作用。

MI队列(n=160338)30天和1-12个月VTE风险分别为0.6%和0.5%,对照队列(n=792384)为0.03%和0.3%。MI队列VTE的30天风险比为23(95%置信区间为20-27),在1年的随访期间有所降低。MI后30天,在低至中度和高合并症的MI患者中,MI和合并症之间的相互作用分别占VTE率的16%和39%。相互作用主要由偏瘫和癌症所致。

由此可见,与一般人群相比,MI后30天VTE风险显著增加。尽管VTE绝对风险较低,但合并症却大大增加了这种风险,尤其是偏瘫和癌症。在这类高危患者中可能需要预防VTE,但需要进一步研究。

原始出处:

Morten Würtz.et al.Comorbidity and risk of venous thromboembolism after hospitalization for first‐time myocardial infarction: A population‐based cohort study.Journal of Thrombosis and Haemostasis.2020.https://onlinelibrary.wiley.com/doi/10.1111/jth.14865

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    2020-11-29 xue8602
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    2021-01-04 changfy
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    2021-04-06 fusion

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