Am J Obstet Gynecol:反复妊娠失败女性围着床期子宫内膜内自然杀伤细胞的比例。

2017-09-25 qinqiyun MedSci原创

复发性流产指反复自然流产3次及以上。

复发性流产指反复自然流产3次及以上。

子宫内自然杀伤细胞是围着床期子宫内膜中的主要白细胞。既往研究发现复发性流产女性的子宫内自然杀伤细胞的百分比与正常对照女性的存在差异,而这一发现存在争议。

现研究人员对复发性流产女性的子宫内自然杀伤细胞的比例与正常对照的进行对比。其在大学附属医院进行一回顾性研究。共有215名女性参与该研究,其中97位复发性流产女性、34位反复移植失败和84位可正常妊娠的女性对照。在月经周期的黄体期激素上升的7天内进行子宫内膜活检。免疫组化检测CD56,遵循标准protocol进行细胞计数。主要评估指标:CD56阳性的子宫自然杀手细胞/总基质细胞的百分比。

在中国女性人群中,作为对照的自然周期有排卵的可妊娠的女性的子宫内自然杀伤细胞占比的中位数是2.5%(0.9-5.3%)。将子宫自然杀伤细胞第5和第95的百分位定义为可信区间的上下限,可信区间为1.2-4.5%。反复妊娠失败的女性子宫内自然杀伤细胞的比例明显高于对照(复发性流产:中位值3.2%,0.6-8.8%;反复移植失败:3.1%,0.8-8.3%)。但在两组(复发性流产16/97、移植失败6/34)中均有一部分人子宫内自然杀伤细胞的比例低于对照组。

本研究建立了正常女性子宫自然杀伤细胞百分比的可信区间。反复妊娠失败女性的子宫内自然杀伤细胞的百分比既有高于该可信区间的,又有低于该可信区间的。

原始出处:


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    2017-09-26 1e0ebf30m03(暂无匿称)

    学习了

    0

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    2017-09-26 三生有幸9135

    学习一下谢谢分享

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