Neurology:荷兰运动神经元疾病的发病率、患病率和地理聚类分析

2021-01-24 MedSci原创 MedSci原创

1998年至2017年,荷兰MND患者的死亡率显著增加,部分原因是荷兰人口老龄化,以及MND风险的地域差异,这表明环境或人群危险因素具有重要作用。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在评估荷兰1998年至2017年期间运动神经元疾病(MND)的发病率、患病率和死亡率的时间趋势,并调查MND病例的地理聚类。

研究人员分析了荷兰个人记录数据库、荷兰MND中心和荷兰神经肌肉疾病患者协会的数据。在这项前瞻性队列研究中,研究人员使用泊松回归评估MND风险的时间趋势,并计算了1694个地区年龄和性别标准化、观察和预期病例。

研究人员确定了7992例MND病例,其发病率为每100000人每年2.64人(95%CI为2.62-2.67),患病率为每100000人每年9.5人(95%CI为9.1-10.0)。最高年龄标准化的患病率和死亡率的年龄在男性中晚于女性(p<0.001)。未经调整的死亡率从1998年的每100000人每年的2.57人增加到2017年的3.86人,增长了53.2%。按年龄和性别进行调整后,MND患者的死亡率上升了14.1%(95%CI为5.7%-23.2%,p<0.001)。地理区域之间的MND相对风险范围为0.78至1.43。

由此可见,1998年至2017年,荷兰MND患者的死亡率显著增加,部分原因是荷兰人口老龄化,以及MND风险的地域差异,这表明环境或人群危险因素具有重要作用。

原始出处:

Adriaan D. de Jongh.et al.Incidence, Prevalence and Geographical Clustering of Motor Neuron Disease in the Netherlands.Neurology.2021.https://doi.org/10.1212/WNL.0000000000011467

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    2021-06-16 yinhl1978
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