Exp Ther Med:全麻甲状腺手术患者联合使用右美托咪定和氟比洛芬酯的好处

2017-11-15 易菁 “罂粟花”微信号

本研究的目的是研究全麻甲状腺手术患者联合使用右美托咪定(Dex)和氟比洛芬酯(FA)对术后镇痛,免疫反应以及认知功能的影响。

背景与目的:本研究的目的是研究全麻甲状腺手术患者联合使用右美托咪定(Dex)和氟比洛芬酯(FA)对术后镇痛,免疫反应以及认知功能的影响。

方  法:研究共纳入100名甲状腺手术患者并随机分为4组:Dex(D)组,FA(F)组,Dex联合FA(DF)组,生理盐水对照(C)组。

结  果:拔管时间和复苏时间,D组和DF组长于C组和F组。拔管后的心率和平均动脉压,F组和D组以及DF组显着低于C组,而DF组显着低于F组。视觉疼痛评分和瑞克镇静躁动评分,DF组显着低于其余三组。T淋巴细胞和B淋巴细胞数量,DF组显着高于其余三组。与F组C组比较,DF组的TNF-和IL-6含量显着减少,但IL-2含量显着增加。

结  论:全麻甲状腺手术患者联合使用Dex和FA能显着降低术后疼痛,减少术后躁动和认知功能障碍,增强免疫功能并促进创口愈合。

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