EJN:心血管健康研究中心房颤动患者的高危颈动脉斑块和缺血性卒中事件

2023-04-21 MedSci原创 MedSci原创 发表于上海

颈动脉狭窄的程度和脆弱斑块的存在都与缺血性卒中的发生无关。

颈动脉疾病是否能改善心房颤动(AF)患者的中风风险分层工具仍不确定。为此,来自澳大利亚阿德莱德大学的学者开展了一项前瞻性人群心血管健康研究,旨在明确房颤患者与闭塞性和非闭塞性颈动脉疾病相关的缺血性卒中的风险。

研究人员纳入了年龄≥65岁的房颤患者。使用多变量考克斯回归分析,探讨颈动脉狭窄百分比、斑块不规则性、回声性和脆弱性(明显不规则、溃疡或低回声斑块)之间的缺血性卒中风险。

结果有1398名参与者被纳入,55.2%为女性,61.7%为65-74岁。94.5%、5%和0.5%的参与者的颈动脉最大狭窄度分别为<50%、50-99%和100%。基于回声性和斑块不规则性的高危斑块分别在25.6%和8.9%的参与者中发现。经过10.9年的中位随访(IQR 7.5-15.6),发生了298次缺血性中风。根据颈动脉狭窄程度(p=0.44)、斑块回声(低风险与高风险,p=0.68)、斑块不规则性(低风险与高风险,p=0.55)和斑块脆弱性(p=0.86),缺血性卒中的发生率没有差异。CHA₂DS₂-VASc评分与缺血性中风的风险增加28%有关(调整后HR=1.28,95%CI:1.18-1.40,P<0.001)。狭窄的最大等级和斑块的脆弱性都与发生缺血性卒中无关(所有的P>0.05)。

由此可见,在这个有房颤的队列中,颈动脉狭窄的程度和脆弱斑块的存在都与缺血性卒中的发生无关。这表明,颈动脉疾病可能不是该人群中缺血性卒中的重要因素

 

参考文献:

High-risk carotid plaques and incident ischemic stroke in patients with atrial fibrillation in the Cardiovascular Health Study. https://doi.org/10.1111/ene.15817

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    2023-04-24 zyyywebmaster 来自浙江省

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    2023-04-22 屋顶瞄爱赏月 来自贵州省

    签到学习

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    2023-04-21 仁术2023 来自吉林省

    不错,学习了。

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    2023-04-22 ms5000000069254713 来自山东省

    心房颤动再合并颈动脉斑块可以说是双重高风险

    0

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