Sci Rep:有氧训练和饮食干预能够降低NAFLD糖尿病前期患者肝脏脂肪含量

2017-11-30 MedSci MedSci原创

相比单独有氧训练或者饮食干预,有氧训练联合饮食干预能够有效降低非酒精性脂肪性肝病糖尿病前期患者肝脏脂肪含量。

研究背景:本研究旨在评估有氧运动(AEx)和富含纤维的饮食是否有效减少非酒精性脂肪性肝病糖尿病前期患者肝脏脂肪含量和增强血糖控制。

研究方法:本研究共招募中国上海杨浦区7家诊所的603例患者。其中,年龄处于50-65岁的患者有115例,符合纳入标准(NAFLD患者,同时存在空腹血糖异常和糖耐量异常)。将115例患者随机分配到有氧训练组(AEx n = 29),饮食干预组(Diet n = 28),有氧训练联合饮食干预组(AED n = 29),非干预组(NI n = 29)。有氧训练每周进行2-3次,每次30-60分钟。饮食干预组提供含38%碳水化合物和12g的膳食纤维的午餐,持续8.6个月。使用H MRS评估肝脏脂肪含量。

研究结果:有氧训练组、饮食干预组和有氧训练联合饮食干预组肝脏脂肪含量显著下降,分别下降24.4%,23.2%,47.9%;相比之下,非干预组肝脏脂肪含量增加了20.9%。然而,相比非干预组(-0.6%).,仅仅有氧训练联合饮食干预组,HbA1c显著下降 (-4.4%, p = 0.01)。

研究结论:相比单独有氧训练或者饮食干预,有氧训练联合饮食干预能够有效降低非酒精性脂肪性肝病糖尿病前期患者肝脏脂肪含量。

原始出处

Cheng S, Ge J, Zhao C, et al. Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial. ci Rep, 2017, Nov 21;7(1):15952. doi: 10.1038/s41598-017-16159-x.

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    2018-08-15 lvygwyt2781
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