Arthritis Rheumatol:单钠尿酸盐结晶沉积在痛风患者的无症状儿子中很常见

2018-05-28 xiangting MedSci原创

痛风患者的无症状儿子经常有高尿酸血症和MSU结晶沉积。在这项研究中,MSU结晶沉积存在于SU>5mg/dl的参与者中。

这项研究旨在估计痛风患者的儿子无症状性单钠尿酸盐(MSU)结晶沉积的患病率和分布情况。

向痛风患者邮寄一封附有邮资的解释性信件,邮寄给他们的儿子(≥20岁)。有兴趣参加研究的儿子回复回执单并接受电话筛选。随后,他们参加了血液和尿液采集、肌肉骨骼超声检查的访问,并对血尿酸(SU)设盲。评估图像的双边征(DCS)、关节内或肌腱内聚集体/痛风石、积液和能量多普勒。使用Logistic回归分析相关性。

131名儿子完成了评估(平均年龄43.80岁,BMI 27.10 kg/m2)。SU≥6mg/dl的参与者占64.1%,29.8%的参与者在≥1个关节中有DCS或关节内聚集体/痛风石。所有伴MSU沉积的参与者均有任一个第1跖趾关节受累。21.4%的参与者有腱内聚集体,并且这与关节内MSU结晶沉积相关(aOR(95%CI)2.96(1.17-7.49))。没有参与者在SU≤5mg/dl时出现MSU结晶沉积,并且24.2%的SU在5-6mg/dl的参与者有超声MSU沉积。MSU结晶沉积与SU升高相关(每增加1mg/dl aOR(95%CI)1.61(1.10-2.36))。

痛风患者的无症状儿子经常有高尿酸血症和MSU结晶沉积。在这项研究中,MSU结晶沉积存在于SU>5mg/dl的参与者中。需要对无痛风家族史的人进行评估,以确定MSU结晶沉积的阈值在一般人群中是否也较低。

原始出处:

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    2018-05-30 zhaojie88
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    2018-05-28 虈亣靌

    对临床很有帮助.学习了

    0

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