JAHA:一般人群吸烟与高敏心肌肌钙蛋白I的关系

2022-01-10 MedSci原创 MedSci原创

在一般人群中,当前和既往吸烟都与较低浓度的hs-cTnI相关。在既往吸烟者中,吸烟包年数和hs-cTnI之间存在剂量反应关系。自戒烟以来的时间与hs-cTnI浓度增加有关。

在普通人群和稳定性缺血性心脏病患者中,心肌肌钙蛋白(cTn)浓度与心力衰竭和心血管死亡的风险密切相关。心肌肌钙蛋白是亚临床心肌损伤的敏感指标,与普通人群心血管事件风险增加有关。尽管心肌肌钙蛋白和吸烟与心血管风险呈正相关,但通过高敏测定法测量的心肌肌钙蛋白I(hs-cTnI)浓度在当前吸烟者中却比从不吸烟者低。吸烟强度和戒烟时间对hs-cTnI的影响尚未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在这项前瞻性、基于人群的HUNT(Trøndelag健康研究)中,研究人员对32028名无心血管疾病的受试者进行了hs-cTnI浓度测量。抽烟习惯被自我报告并分类为从不吸烟(n=14559)、既往吸烟(n=14248)和当前吸烟者(n=3221)。

研究人员发现当前吸烟者的hs-cTnI浓度显著低于从不吸烟者(P<0.001)。在调整后的模型中,当前吸烟者(-17.3%;95%CI为-20.6至-13.9%)和既往吸烟者(-6.6%;95%CI为-8.7至-4.5%)hs‐cTnI浓度均显著降低。

在前吸烟者中,较高的吸烟负担(>10包-年)与较低的hs-cTnI浓度相关。自戒烟以来的时间与hs-cTnI浓度的增加呈剂量依赖性相关(趋势P<0.001),并且戒烟30年以上的受试者hs-cTnI浓度与从不吸烟者相当。

由此可见,在一般人群中,当前和既往吸烟都与较低浓度的hs-cTnI相关。在既往吸烟者中,吸烟包年数和hs-cTnI之间存在剂量反应关系。自戒烟以来的时间与hs-cTnI浓度增加有关。

原始出处:

Julia Brox Skranes,et al.Tobacco Consumption and High‐Sensitivity Cardiac Troponin I in the General Population: The HUNT Study.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021776

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    2022-01-12 zhaohui6731
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    2022-01-11 ms6000000875120767

    好东西

    0

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    2022-01-10 robbert123

    学习

    0

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    2022-01-10 孤独的边城浪子

    叼叼叼

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