J Gastroenterology:骨骼肌质量与脂肪的比值增加可以预测非酒精性脂肪性肝病患者转氨酶的下降

2018-10-02 MedSci MedSci原创

有研究表明骨骼肌质量作为一种营养学指标与多种疾病的预后存在显着关系,因此,研究人员进行了一项回顾性研究来确定骨骼肌和体脂对非酒精性脂肪性肝病(NAFLD)患者肝功能的影响。

背景及目的
有研究表明骨骼肌质量作为一种营养学指标与多种疾病的预后存在显着关系,因此,研究人员进行了一项回顾性研究来确定骨骼肌和体脂对非酒精性脂肪性肝病(NAFLD)患者肝功能的影响。

方法
研究人员在本研究纳入了219例NAFLD患者中,其中139例患者在基线和基线后≥1年时用体脂仪Inbody720测量其机体成分,以阐明肝功能与骨骼肌和体脂肪量变化之间的关系。采用logistic多变量分析确定影响低骨骼肌质量指数的因素(骨骼肌质量指数(SMI),男性定义为7 kg / m2,女性定义为5.7 kg / m2)和骨骼肌质量与体脂肪质量比(SF比率)。

结果
在入组的219名患者中,27名(12.3%)患有低SMI。患者年龄(> 70岁)和女性被确认为低SMI的危险因素。肝纤维化与SMI无关。在基线和12个月后随访的队列中,转氨酶活性,体脂肪量和SMI随时间显着降低。SF比率的变化与肝功能的变化显着相关。SF比例增加[男性风险比(HR)10.99,女性(HR)6.849]是ALT降低的预测因子。

结论
研究人员观察到在NAFLD患者中,即使在NAFLD的早期阶段,SMI也会降低。NAFLD的治疗策略中需重视体脂肪量的变化并且还需维持骨骼肌的治疗的增加。

原始出处:

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createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Oct 27 15:26:00 CST 2018, time=2018-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064504, encodeId=cc2e206450479, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Oct 14 00:26:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810100, encodeId=529e18101000c, content=<a href='/topic/show?id=70f484349b5' target=_blank style='color:#2F92EE;'>#脂肪性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84351, encryptionId=1e1584351b2, topicName=脂肪性肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46224431741, createdName=wwzzly, createdTime=Wed Sep 11 21:26:00 CST 2019, time=2019-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711670, encodeId=a7e71e11670ba, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Nov 22 05:26:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072318, encodeId=34f320e2318c9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 16 06:26:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348103, encodeId=38a5348103f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Oct 06 00:01:37 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]
    2019-05-17 qjddjq
  5. [GetPortalCommentsPageByObjectIdResponse(id=2017957, encodeId=1e65201e957b1, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Jul 19 05:26:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673437, encodeId=13d016e343726, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2017957, encodeId=1e65201e957b1, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Jul 19 05:26:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673437, encodeId=13d016e343726, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=2072318, encodeId=34f320e2318c9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 16 06:26:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348103, encodeId=38a5348103f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Oct 06 00:01:37 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2017957, encodeId=1e65201e957b1, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Jul 19 05:26:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673437, encodeId=13d016e343726, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Oct 27 15:26:00 CST 2018, time=2018-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064504, encodeId=cc2e206450479, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Oct 14 00:26:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810100, encodeId=529e18101000c, content=<a href='/topic/show?id=70f484349b5' target=_blank style='color:#2F92EE;'>#脂肪性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=2072318, encodeId=34f320e2318c9, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 16 06:26:00 CST 2019, time=2019-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348103, encodeId=38a5348103f3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Oct 06 00:01:37 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]
    2019-07-16 许安
  9. [GetPortalCommentsPageByObjectIdResponse(id=2017957, encodeId=1e65201e957b1, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Jul 19 05:26:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673437, encodeId=13d016e343726, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]
    2018-10-06 121832a9m88暂无昵称

    学习了

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=1333082, encodeId=58051333082c8, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Thu Oct 04 06:26:00 CST 2018, time=2018-10-04, status=1, ipAttribution=)]

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