J Eur Acad Dermatol Venereol:外用非那雄胺可明显改善毛发数量,且耐受性良好

2022-05-02 sunshine MedSci原创

口服非那雄胺是治疗男性雄性激素性脱发(AGA)的一种成熟的治疗方法,但长期治疗并不总是为患者接受。现已开发出一种外用非那雄胺制剂,通过特异性作用于毛囊,最大限度地减少全身暴露。

口服非那雄胺是治疗男性雄性激素性脱发(AGA)的一种成熟的治疗方法,但长期治疗并不总是为患者接受。现已开发出一种外用非那雄胺制剂,通过特异性作用于毛囊,最大限度地减少全身暴露。发表于J Eur Acad Dermatol Venereol的一项随机对照试验评价了外用非那雄胺的疗效和安全性,并分析全身暴露情况和与口服非那雄胺相比的总体效益。

这项随机、双盲、双假、平行组、24周的研究是在欧洲45个地点的成年男性AGA门诊病人中进行的。研究人员对口服非那雄胺的疗效和安全性进行了评估。同时,测量了非那雄胺、睾酮和双氢睾酮(DHT)的浓度。

 

结果,在458名随机患者中,323人完成了研究,446人接受了安全性评估。在第24周(主要疗效终点),外用非那雄胺的靶区毛发数量(TAHC)较基线变化明显大于安慰剂组(校正后的平均变化为20.2根VS. 6.7根;P<0.001),外用和口服非那雄胺在数量上相似。在第12周TAHC相对基线的变化和第24周研究者评估的患者头发生长/脱落相对基线的变化方面,观察到外用非那雄胺而非安慰剂的有益方面的统计学差异。不良事件的发生率和类型以及停药原因在外用非那雄胺和安慰剂之间没有意义的差异。没有严重的不良事件与治疗有关。由于外用与口服非那雄胺的最大血浆非那雄胺浓度比基线低100倍,且平均血清DHT浓度比基线低(34.5% VS. 55.6%),因此,外用非那雄胺减少DHT而引起的系统性不良反应的可能性较小。

综上所述,该研究结果表明,与安慰剂相比,外用非那雄胺可明显改善毛发数量,且耐受性良好。其效果与口服非那雄胺相似,但其全身暴露量明显较低,对血清DHT浓度的影响也较小。

 

原始出处:

 

B M Piraccini, et al., Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. J Eur Acad Dermatol Venereol. 2022 Feb;36(2):286-294. doi: 10.1111/jdv.17738.  

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    2022-11-27 lishizhe
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    2022-05-02 病毒猎手

    #非那雄胺#治疗#脱发#尤其是#脂溢性脱发#,应该有效的,但是副作用#阳萎#,怎么办?到底如何选择??

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1652010, encodeId=3da116520106d, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Sun Nov 27 18:24:27 CST 2022, time=2022-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232967, encodeId=2ce3123296e05, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a><a href='/topic/show?id=23eb99e1815' target=_blank style='color:#2F92EE;'>#非那雄胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发), TopicDto(id=99718, encryptionId=23eb99e1815, topicName=非那雄胺)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 17 12:20:39 CST 2022, time=2022-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216358, encodeId=06cf12163581c, content=<a href='/topic/show?id=23eb99e1815' target=_blank style='color:#2F92EE;'>#非那雄胺#</a>治疗<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>尤其是<a href='/topic/show?id=735810451e31' target=_blank style='color:#2F92EE;'>#脂溢性脱发#</a>,应该有效的,但是副作用<a href='/topic/show?id=aa92104518dc' target=_blank style='color:#2F92EE;'>#阳萎#</a>,怎么办?到底如何选择??, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99718, encryptionId=23eb99e1815, topicName=非那雄胺), TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发), TopicDto(id=104517, encryptionId=735810451e31, topicName=脂溢性脱发), TopicDto(id=104518, encryptionId=aa92104518dc, topicName=阳萎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon May 02 16:53:57 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216351, encodeId=975312163518f, content=效果的确不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcb46547057, createdName=ms6000001757638201, createdTime=Mon May 02 16:28:20 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216339, encodeId=70211216339cf, content=认真学习~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfb41991958, createdName=xulv123, createdTime=Mon May 02 15:42:44 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216329, encodeId=45be1216329cd, content=很前沿的咨询,谢谢分享!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65aa5643711, createdName=小白努力长高高, createdTime=Mon May 02 15:28:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417749, encodeId=e7eb141e749ab, content=<a href='/topic/show?id=aada80351ae' target=_blank style='color:#2F92EE;'>#耐受性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80351, encryptionId=aada80351ae, topicName=耐受性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=43843300457, createdName=Smile2681, createdTime=Mon May 02 06:24:27 CST 2022, time=2022-05-02, status=1, ipAttribution=)]
    2022-05-02 ms6000001757638201

    效果的确不错。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1652010, encodeId=3da116520106d, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Sun Nov 27 18:24:27 CST 2022, time=2022-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1232967, encodeId=2ce3123296e05, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a><a href='/topic/show?id=23eb99e1815' target=_blank style='color:#2F92EE;'>#非那雄胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发), TopicDto(id=99718, encryptionId=23eb99e1815, topicName=非那雄胺)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 17 12:20:39 CST 2022, time=2022-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216358, encodeId=06cf12163581c, content=<a href='/topic/show?id=23eb99e1815' target=_blank style='color:#2F92EE;'>#非那雄胺#</a>治疗<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>尤其是<a href='/topic/show?id=735810451e31' target=_blank style='color:#2F92EE;'>#脂溢性脱发#</a>,应该有效的,但是副作用<a href='/topic/show?id=aa92104518dc' target=_blank style='color:#2F92EE;'>#阳萎#</a>,怎么办?到底如何选择??, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99718, encryptionId=23eb99e1815, topicName=非那雄胺), TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发), TopicDto(id=104517, encryptionId=735810451e31, topicName=脂溢性脱发), TopicDto(id=104518, encryptionId=aa92104518dc, topicName=阳萎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon May 02 16:53:57 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216351, encodeId=975312163518f, content=效果的确不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcb46547057, createdName=ms6000001757638201, createdTime=Mon May 02 16:28:20 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216339, encodeId=70211216339cf, content=认真学习~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfb41991958, createdName=xulv123, createdTime=Mon May 02 15:42:44 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1216329, encodeId=45be1216329cd, content=很前沿的咨询,谢谢分享!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65aa5643711, createdName=小白努力长高高, createdTime=Mon May 02 15:28:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417749, encodeId=e7eb141e749ab, content=<a href='/topic/show?id=aada80351ae' target=_blank style='color:#2F92EE;'>#耐受性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80351, encryptionId=aada80351ae, topicName=耐受性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=43843300457, createdName=Smile2681, createdTime=Mon May 02 06:24:27 CST 2022, time=2022-05-02, status=1, ipAttribution=)]
    2022-05-02 xulv123

    认真学习~~

    0

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    2022-05-02 小白努力长高高

    很前沿的咨询,谢谢分享!!!

    0

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