Med Oncol:乳腺癌脑转移的风险及预后评估

2014-12-06 MedSci译 MedSci原创

Med Oncol:乳腺癌脑转移的风险及预后评估 研究背景:乳腺癌一旦发生脑转移对于医生和患者来说是一个巨大挑战,脑转移患者有更差的预后,初诊后2年之内是发生脑转移的高峰期,已知的脑转移危险因素包括较小的年龄、低分化肿瘤、雌激素受体(ER)阴性或三阴性乳腺癌(TNBC)、HER2阳性。 研究目的:本文拟研究乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异。 研究方案:纳入人

研究背景:乳腺癌一旦发生脑转移对于医生和患者来说是一个巨大挑战,脑转移患者有更差的预后,初诊后2年之内是发生脑转移的高峰期,已知的脑转移危险因素包括较小的年龄、低分化肿瘤、雌激素受体(ER)阴性或三阴性乳腺癌(TNBC)、HER2阳性。 研究目的: 本文拟研究乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异。 研究方案: 纳入人群来源于德国滨根大学妇科部的80名脑转移患者,回顾性分析80名经治疗及随访的初诊无转移可手术的乳腺癌患者,治疗方式根据适应情况接受了赫赛汀及雌激素内分泌治疗,脑转移通过神经扫描仪诊断(neuro-scan CCT/MR),收集临床病理资料(初诊时分期、年龄、组织学级别、淋巴结状态、ER/PR/HER2状态、),记录经NMR/CCT发现脑转移的数量以及初诊至脑转移发生的时间,分析各种临床病理因素与预后的相关性,对资料的单因素及多因素分析使用PASW程序完成、生存曲线用Kaplan-Meier分析。 研究结果: 初诊时患者临床病理特征见table1,我们可以看出最常见的病理类型是组织学3级、浸润性导管癌。组织学3级、腋窝淋巴结转移、三阴性状态是发生

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    2015-06-30 tzf419

    学习了,很有收获

    0

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    2015-04-30 minlingfeng
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    2014-12-13 cbp

    乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异分析挺到位的

    0

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