JAMA:肿瘤坏死因子拮抗剂与癌症风险升高无关

2015-01-20 高晓方 翻译 中国医学论坛报

丹麦一项队列研究纳入56146例年龄≥15岁的炎症性肠病(IBD)患者,并对肿瘤坏死因子(TNF-α)拮抗剂暴露是否升高患者的癌症风险进行评估。结果显示,中位3.7年随访期间,TNF-α拮抗剂暴露和未暴露患者的癌症发病率分别为1.8%和6.7%。依据自首次TNF-α拮抗剂暴露时间和用药次数进行分析时,癌症风险均未出现显著升高。部位特异性癌症亦未显著增多。论文发表于《美国医学会杂志》。

丹麦一项队列研究纳入56146例年龄≥15岁的炎症性肠病(IBD)患者,并对肿瘤坏死因子(TNF-α)拮抗剂暴露是否升高患者的癌症风险进行评估。结果显示,中位3.7年随访期间,TNF-α拮抗剂暴露和未暴露患者的癌症发病率分别为1.8%和6.7%。依据自首次TNF-α拮抗剂暴露时间和用药次数进行分析时,癌症风险均未出现显著升高。部位特异性癌症亦未显著增多。论文发表于《美国医学会杂志》。


Figure 1.Formation of Study Cohort

点评:此结果与既往结论一致。尽管免疫抑制药物巯嘌呤可升高淋巴瘤和非黑色素瘤皮肤癌风险,但TNF-α拮抗剂与癌症风险升高无确定相关性。

原始出处:

Nyboe Andersen N1, Pasternak B1, Basit S1, Andersson M1, Svanström H1, Caspersen S2, Munkholm P2, Hviid A1, Jess T1.Association between tumor necrosis factor-α antagonists and risk of cancer in patients with inflammatory bowel disease.JAMA. 2014 Jun 18;311(23):2406-13. doi: 10.1001/jama.2014.5613.[pdf free]

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