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Macromol Biosci：Ti-VH@PVA笼或可用于预防脊柱外科手术后的感染

2020-02-19 不详 网络

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为了防止手术部位感染（SSI），已经研究了许多涂料。然而，使用传统的钛（Ti）笼在表面上的抗菌涂层显示出较弱的附着力，导致脊柱手术后预防SSI的功效较低。本文中，开发了3D打印的Ti笼与药物释放系统相结合，用于原位释放药物和杀死细菌，从而在体外和体内都可预防SSI。首先，通过电子束熔化（EBM）方法设计和制备3D打印的Ti保持架。其次，含有亲水性万古霉素盐酸盐（VH）的聚乙烯醇（PVA）散布在3D

为了防止手术部位感染（SSI），已经研究了许多涂料。然而，使用传统的钛（Ti）笼在表面上的抗菌涂层显示出较弱的附着力，导致脊柱手术后预防SSI的功效较低。本文中，开发了3D打印的Ti笼与药物释放系统相结合，用于原位释放药物和杀死细菌，从而在体外和体内都可预防SSI。

首先，通过电子束熔化（EBM）方法设计和制备3D打印的Ti保持架。其次，含有亲水性万古霉素盐酸盐（VH）的聚乙烯醇（PVA）散布在3D打印的多孔Ti（Ti-VH @ PVA）笼子的表面上。

结果显示，Ti-VH @ PVA笼子在体外放置超过7天后，对三种常见细菌均显示出有效的药物释放特性和出色的杀菌效果。此外，Ti-VH @ PVA笼在兔SSI模型中显示出对金黄色葡萄球菌相关炎症的可靠抑制和有效的骨再生能力。

结果表明，Ti-VH@PVA笼具有预防脊柱外科手术后SSI的潜在优势。

原始出处：

Li Y, Li L1, et al., 3D-Printed Titanium Cage with PVA-Vancomycin Coating Prevents Surgical Site Infections (SSIs). Macromol Biosci. 2020 Feb 17:e1900394. doi: 10.1002/mabi.201900394.

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    2020-04-25 jiafufeng@yaho

    #CRO#

    0

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    2020-10-27 yb6560

    #MAC#

    0

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    2020-07-28 sunylz

    #Bio#

    0

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    2021-02-02 pandamao2010

    #脊柱外科手术#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1857863, encodeId=2928185e863b3, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Apr 25 18:06:00 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1996332, encodeId=869f199633227, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Oct 27 09:06:00 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918988, encodeId=2c83191898882, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 28 15:06:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004001, encodeId=ecb7200400198, content=<a href='/topic/show?id=51078452eb4' target=_blank style='color:#2F92EE;'>#脊柱外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84527, encryptionId=51078452eb4, topicName=脊柱外科手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Tue Feb 02 19:06:00 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343389, encodeId=341613433891c, content=<a href='/topic/show?id=d3ea4293676' target=_blank style='color:#2F92EE;'>#外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400456, encodeId=2cc6140045626, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509674, encodeId=a0e415096e406, content=<a href='/topic/show?id=ce2b84525db' target=_blank style='color:#2F92EE;'>#脊柱外科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84525, encryptionId=ce2b84525db, topicName=脊柱外科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d54710125875, createdName=fengting6, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
    2020-02-21 ms7524819409032184

    #外科手术#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1857863, encodeId=2928185e863b3, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Apr 25 18:06:00 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1996332, encodeId=869f199633227, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Oct 27 09:06:00 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918988, encodeId=2c83191898882, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 28 15:06:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004001, encodeId=ecb7200400198, content=<a href='/topic/show?id=51078452eb4' target=_blank style='color:#2F92EE;'>#脊柱外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84527, encryptionId=51078452eb4, topicName=脊柱外科手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Tue Feb 02 19:06:00 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343389, encodeId=341613433891c, content=<a href='/topic/show?id=d3ea4293676' target=_blank style='color:#2F92EE;'>#外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400456, encodeId=2cc6140045626, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509674, encodeId=a0e415096e406, content=<a href='/topic/show?id=ce2b84525db' target=_blank style='color:#2F92EE;'>#脊柱外科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84525, encryptionId=ce2b84525db, topicName=脊柱外科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d54710125875, createdName=fengting6, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
    2020-02-21 10518094zz

    #ACR#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1857863, encodeId=2928185e863b3, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Apr 25 18:06:00 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1996332, encodeId=869f199633227, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Oct 27 09:06:00 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918988, encodeId=2c83191898882, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 28 15:06:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004001, encodeId=ecb7200400198, content=<a href='/topic/show?id=51078452eb4' target=_blank style='color:#2F92EE;'>#脊柱外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84527, encryptionId=51078452eb4, topicName=脊柱外科手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Tue Feb 02 19:06:00 CST 2021, time=2021-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343389, encodeId=341613433891c, content=<a href='/topic/show?id=d3ea4293676' target=_blank style='color:#2F92EE;'>#外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400456, encodeId=2cc6140045626, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509674, encodeId=a0e415096e406, content=<a href='/topic/show?id=ce2b84525db' target=_blank style='color:#2F92EE;'>#脊柱外科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84525, encryptionId=ce2b84525db, topicName=脊柱外科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d54710125875, createdName=fengting6, createdTime=Fri Feb 21 05:06:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
    2020-02-21 fengting6

    #脊柱外科#

    0