阜外研究:房颤心衰患者有肥胖悖论现象,无心衰的房颤患者没有

2018-04-09 文韬 中国循环杂志

阜外医院冯广迅和杨艳敏等研究发现,伴有心衰的房颤患者死亡风险高于不伴心衰的房颤患者,而且两者预测死亡的危险因素也不同。


阜外医院冯广迅和杨艳敏等研究发现,伴有心衰房颤患者死亡风险高于不伴心衰的房颤患者,而且两者预测死亡的危险因素也不同。
 
研究中有65%的心衰房颤患者为持续性房颤,1年死亡率为19.1%;而无心衰的房颤患者仅36%为持续性房颤,1年死亡率11.0%。
 
多因素校正后,研究发现,对于没有心衰的房颤患者,心率和合并慢阻肺可预测死亡。
 
而对于有心衰的房颤患者,体重指数越高和血压越高的患者,其死亡风险反而较低。作者认为,这其实就是心衰患者中存在“肥胖悖论 ”的表现。
 
无论是否存在心衰,与房颤作为主要诊断者相比,房颤作为次要诊断的患者预后均较差,这是因为以房颤作为次要诊断的患者可能因合并的心衰、肺炎及心肌梗死入院,本身代表病情较重,预后更差,故而临床中需针对患者的主要诊断予以治疗。
 
两组分别还有8.8%和6.8%的患者发生率卒中或体循环栓塞。但仅有13.4%和17.7%的患者服用华法林抗凝。
 
该研究在全国20家医院连续入选急诊的房颤患者2 015例,根据是否伴有心衰将患者分为伴心衰组(n=753)和不伴心衰组(n=1 263),并随访了一年,比较了伴或不伴心衰的房颤患者特征、预后和死亡的危险因素。
 
原始出处:

冯广迅,杨艳敏等.心房颤动伴或不伴心力衰竭患者的死亡危险因素分析.中国循环杂志. 2018;33:161-165.

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