Diabetes Obes Metab:低碳水化合物饮食对肥胖个体长期减肥的疗效

2022-04-09 MedSci原创 MedSci原创

与非碳水化合物限制饮食相比,低碳水化合物饮食与更大的短期体重减轻相关,并对心血管风险因素有长期有利的影响。

肥胖会增加2型糖尿病、心血管疾病、恶性肿瘤和死亡率的风险。控制肥胖的目的是改善整体健康,而不仅仅是减肥。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,该研究旨在评估低碳水化合物饮食是否与肥胖人群的减肥和健康差异相关,并评估他们的心血管和肾脏安全性。

研究人员通过对MedLine和Embase在线数据库进行广泛搜索检索,对超过3个月的随机对照试验进行了meta分析,这些试验比较了BMI为>30 kg/m2的受试者接受低碳水化合物饮食和对照饮食的减肥效果。

研究人员检索了25项试验。与对照组相比,低碳水化合物饮食与3-4个月(MD为-2.59[-3.93,-1.25]kg)和6-8个月(MD为-2.64[-4.32,-0.95])的体重降低显著相关,而10-14个月和18-30个月的体重无差异。与对照组相比,低碳水化合物饮食在3-4个月时显著降低了BMI (-1.66[-2.70,-0.61]kg/m2),但在其他时间点没有相关。

由于只有四项试验报告了有关肾功能和心理参数的数据,因此无法评估肾安全性和对幸福感的影响。各时间点空腹血糖差异无统计学意义。长期观察发现,总胆固醇、低密度脂蛋白胆固醇和血压没有显著差异,而甘油三酯长期下降(18-30个月时为23.26 [-45.53,-0.98]mg/dl),高密度脂蛋白胆固醇增加,18-30个月时MD为4.94 [0.30, 9.57] mg/dl)。

由此可见,与非碳水化合物限制饮食相比,低碳水化合物饮食与更大的短期体重减轻相关,并对心血管风险因素有长期有利的影响。在低碳水化合物饮食被推荐为肥胖者的首选饮食之前,还需要进一步的证据来证实其长期有效性和肾脏的安全性。
 
原始出处:
 
Giovanni Antonio Silverii,et al.Effectiveness of Low Carbohydrate diets for long-term weight loss in obese individuals: a meta-analysis of randomized controlled trials.Diabetes Obesity & Metabolism.2022.https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14709

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createdName=wangyang7958, createdTime=Sat Apr 23 23:58:29 CST 2022, time=2022-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902726, encodeId=b1691902e26c3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Nov 11 10:58:29 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897000, encodeId=a271189e00012, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 15 18:58:29 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640110, encodeId=9703164011051, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri May 13 06:58:29 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761892, encodeId=ab971e6189282, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 28 13:58:29 CST 2022, time=2022-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345137, encodeId=a5f2134513ed9, content=<a href='/topic/show?id=c2462629612' target=_blank style='color:#2F92EE;'>#低碳水化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26296, encryptionId=c2462629612, topicName=低碳水化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464403, encodeId=21e8146440301, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596233, encodeId=acd21596233e0, content=<a href='/topic/show?id=9d0e2629e5c' target=_blank style='color:#2F92EE;'>#低碳水化合物饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26297, encryptionId=9d0e2629e5c, topicName=低碳水化合物饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713a18344324, createdName=wodejia-dayu, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245923, encodeId=9777124592398, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Apr 09 13:58:29 CST 2022, time=2022-04-09, status=1, ipAttribution=)]
    2022-05-15 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1888426, encodeId=eeee188842665, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri May 27 22:58:29 CST 2022, time=2022-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906471, encodeId=8cae19064e1a3, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Apr 23 23:58:29 CST 2022, time=2022-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902726, encodeId=b1691902e26c3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Nov 11 10:58:29 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897000, encodeId=a271189e00012, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 15 18:58:29 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640110, encodeId=9703164011051, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri May 13 06:58:29 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761892, encodeId=ab971e6189282, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 28 13:58:29 CST 2022, time=2022-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345137, encodeId=a5f2134513ed9, content=<a href='/topic/show?id=c2462629612' target=_blank style='color:#2F92EE;'>#低碳水化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26296, encryptionId=c2462629612, topicName=低碳水化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464403, encodeId=21e8146440301, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596233, encodeId=acd21596233e0, content=<a href='/topic/show?id=9d0e2629e5c' target=_blank style='color:#2F92EE;'>#低碳水化合物饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26297, encryptionId=9d0e2629e5c, topicName=低碳水化合物饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713a18344324, createdName=wodejia-dayu, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245923, encodeId=9777124592398, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Apr 09 13:58:29 CST 2022, time=2022-04-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1888426, encodeId=eeee188842665, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri May 27 22:58:29 CST 2022, time=2022-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906471, encodeId=8cae19064e1a3, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Apr 23 23:58:29 CST 2022, time=2022-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902726, encodeId=b1691902e26c3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Nov 11 10:58:29 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897000, encodeId=a271189e00012, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 15 18:58:29 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640110, encodeId=9703164011051, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri May 13 06:58:29 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761892, encodeId=ab971e6189282, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 28 13:58:29 CST 2022, time=2022-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345137, encodeId=a5f2134513ed9, content=<a href='/topic/show?id=c2462629612' target=_blank style='color:#2F92EE;'>#低碳水化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26296, encryptionId=c2462629612, topicName=低碳水化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464403, encodeId=21e8146440301, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596233, encodeId=acd21596233e0, content=<a href='/topic/show?id=9d0e2629e5c' target=_blank style='color:#2F92EE;'>#低碳水化合物饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26297, encryptionId=9d0e2629e5c, topicName=低碳水化合物饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713a18344324, createdName=wodejia-dayu, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245923, encodeId=9777124592398, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Apr 09 13:58:29 CST 2022, time=2022-04-09, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1888426, encodeId=eeee188842665, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri May 27 22:58:29 CST 2022, time=2022-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906471, encodeId=8cae19064e1a3, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun May 15 18:58:29 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640110, encodeId=9703164011051, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri May 13 06:58:29 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761892, encodeId=ab971e6189282, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 28 13:58:29 CST 2022, time=2022-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345137, encodeId=a5f2134513ed9, content=<a href='/topic/show?id=c2462629612' target=_blank style='color:#2F92EE;'>#低碳水化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26296, encryptionId=c2462629612, topicName=低碳水化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464403, encodeId=21e8146440301, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Mon Apr 11 01:58:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596233, encodeId=acd21596233e0, content=<a href='/topic/show?id=9d0e2629e5c' target=_blank style='color:#2F92EE;'>#低碳水化合物饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26297, encryptionId=9d0e2629e5c, topicName=低碳水化合物饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713a18344324, createdName=wodejia-dayu, createdTime=Mon Apr 11 01:58:29 CST 2022, 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  8. 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    2022-04-11 yuanming9
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    2022-04-09 CHANGE

    什么时候有懒人用的减肥神药?

    0

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