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Diabetes Care：每日补充叶酸可降低妊娠期糖尿病的发病风险

2019-07-15 sunshine 译 MedSci原创

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本研究旨在通过检查孕前习惯性叶酸摄入量与妊娠期糖尿病（GDM）风险之间的关系，确定GDM的新型可改变危险因素。　　研究纳入了护士健康研究II中的14553名女性，在1991年至2001年的问卷调查中这些女性至少有一次单胎妊娠。使用每4年一次的食物频率问卷评估其孕前总叶酸、叶酸补充剂和食物叶酸的摄入量。GDM事件由自我报告的医生诊断确定。使用对数二项式模型估计GDM的相对风险（RR），并校正人口统计

本研究旨在通过检查孕前习惯性叶酸摄入量与妊娠期糖尿病（GDM）风险之间的关系，确定GDM的新型可改变危险因素。
　　
研究纳入了护士健康研究II中的14553名女性，在1991年至2001年的问卷调查中这些女性至少有一次单胎妊娠。使用每4年一次的食物频率问卷评估其孕前总叶酸、叶酸补充剂和食物叶酸的摄入量。GDM事件由自我报告的医生诊断确定。使用对数二项式模型估计GDM的相对风险（RR），并校正人口统计学指标、生活方式和饮食因素。
　　
结果显示，研究随访中，20199次妊娠中发生了824例GDM事件。叶酸摄入量足够（≥400μg/天）的女性与摄入不足（<400μg/天）的女性相比，GDM的RR为0.83（95％CI为0.72-0.95，P=0.007）。这种关联与补充叶酸摄入量相关。与没有补充叶酸的女性相比，补充叶酸摄入量为1-399、400-599和≥600μg/天的女性GDM的RR分别为0.83、0.77和0.70（趋势P=0.002）。校正多种维生素和其他微量营养素以及计划妊娠的女性后，补充叶酸摄入量与GDM风险之间的关联仍然存在。
　　
总之，该研究结果表明，妊娠前习惯性补充较高叶酸摄入量的与较低的GDM风险显著相关。如果得到证实，这些研究结果表明，孕前补充叶酸是一种新的低成本途径用以降低GDM的发生风险。

原始出处

Li M, Li S, et al., Prepregnancy Habitual Intakes of Total, Supplemental, and Food Folate and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care. 2019 Jun;42(6):1034-1041. doi: 10.2337/dc18-2198.

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    2020-06-23 木头人513

    #Diabetes#

    0

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    2019-11-25 ms9608593228839890

    #DIA#

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    2020-06-10 ms5439512287675881

    #BET#

    0

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    2019-08-06 jyzxjiangqin

    每日补充叶酸可降低血压。

    0

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    2019-07-17 wjcjjian

    #妊娠期#

    0

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    2019-07-17 shenxlcyp

    #妊娠期糖尿病#

    0

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    2019-07-16 184****9840

    学习了，谢谢分享。

    0

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    2019-07-15 misszhang

    谢谢MedSci提供最新的资讯

    0