2019 ESMO:罗氏的PD-L1单抗Tecentriq与VEGF单抗Avastin联合针对无法切除的肝细胞癌患者的Ib期研究中显示出令人鼓舞的结果

2019-09-27 不详 MedSci原创

在2019年欧洲医学肿瘤学会(ESMO)大会上,罗氏公布将血管内皮生长因子单抗Avastin(贝伐单抗)与PD-L1单抗Tecentriq(atezolizumab)联合在未接受过全身治疗、不可切除的肝细胞癌(HCC)(最常见的肝癌形式)患者中Ib期临床的疗效和安全性研究结果。

在2019年欧洲医学肿瘤学会(ESMO)大会上,罗氏公布将血管内皮生长因子单抗Avastin(贝伐单抗)与PD-L1单抗Tecentriq(atezolizumab)联合在未接受过全身治疗、不可切除的肝细胞癌(HCC)(最常见的肝癌形式)患者中Ib期临床的疗效和安全性研究结果。

研究表明,接受Tecentriq和Avastin联合治疗未接受过全身性治疗且无法切除的肝细胞癌患者的客观缓解率达到36%。与Tecentriq单药治疗相比,Tecentriq和Avastin的组合可将疾病恶化或死亡的风险降低45%。

阿瓦斯汀除了具有公认的抗血管生成作用外,还可以通过抑制血管内皮生长因子(VEGF)相关的免疫抑制作用,促进T细胞肿瘤浸润并实现T的激活和活化,进一步增强Tecentriq恢复抗癌免疫力的能力。

Tecentriq是一种单克隆抗体,旨在与称为PD-L1的蛋白质结合,该蛋白质在肿瘤细胞和肿瘤浸润性免疫细胞上表达,阻断其与PD-1和B7.1受体的相互作用。通过抑制PD-L1,Tecentriq可以激活T细胞。

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    2019-10-02 循证小兵
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    2020-04-28 liuhuangbo
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href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Fri Jan 24 04:51:00 CST 2020, time=2020-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863456, encodeId=bc3a186345683, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Jan 23 17:51:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255025, encodeId=8cdb1255025d7, content=<a href='/topic/show?id=be71139214f' target=_blank style='color:#2F92EE;'>#PD-L1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13921, encryptionId=be71139214f, topicName=PD-L1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280988, encodeId=1ccb1280988d8, content=<a href='/topic/show?id=50d6e0215a' target=_blank style='color:#2F92EE;'>#ESMO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7021, encryptionId=50d6e0215a, topicName=ESMO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368534, encodeId=a5db13685342c, content=<a href='/topic/show?id=25aa1833e88' target=_blank style='color:#2F92EE;'>#VEGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18337, encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=)]
    2020-06-06 bioon3
  5. [GetPortalCommentsPageByObjectIdResponse(id=1712105, encodeId=e1551e12105c4, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Apr 04 23:51:00 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796706, encodeId=e9a21e967066f, content=<a href='/topic/show?id=e37618298aa' target=_blank style='color:#2F92EE;'>#VAST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18298, encryptionId=e37618298aa, topicName=VAST)], attachment=null, authenticateStatus=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255025, encodeId=8cdb1255025d7, content=<a href='/topic/show?id=be71139214f' target=_blank style='color:#2F92EE;'>#PD-L1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13921, encryptionId=be71139214f, topicName=PD-L1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280988, encodeId=1ccb1280988d8, content=<a href='/topic/show?id=50d6e0215a' target=_blank style='color:#2F92EE;'>#ESMO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7021, encryptionId=50d6e0215a, topicName=ESMO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368534, encodeId=a5db13685342c, content=<a href='/topic/show?id=25aa1833e88' target=_blank style='color:#2F92EE;'>#VEGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18337, encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=)]
    2020-05-21 shock_melon
  6. [GetPortalCommentsPageByObjectIdResponse(id=1712105, encodeId=e1551e12105c4, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Apr 04 23:51:00 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796706, encodeId=e9a21e967066f, content=<a href='/topic/show?id=e37618298aa' target=_blank style='color:#2F92EE;'>#VAST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18298, encryptionId=e37618298aa, topicName=VAST)], attachment=null, authenticateStatus=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255025, encodeId=8cdb1255025d7, content=<a href='/topic/show?id=be71139214f' target=_blank style='color:#2F92EE;'>#PD-L1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13921, encryptionId=be71139214f, topicName=PD-L1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280988, encodeId=1ccb1280988d8, content=<a href='/topic/show?id=50d6e0215a' target=_blank style='color:#2F92EE;'>#ESMO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7021, encryptionId=50d6e0215a, topicName=ESMO)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. 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createdBy=7460166, createdName=zhang92560, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368534, encodeId=a5db13685342c, content=<a href='/topic/show?id=25aa1833e88' target=_blank style='color:#2F92EE;'>#VEGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18337, encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sun Sep 29 12:51:00 CST 2019, time=2019-09-29, status=1, ipAttribution=)]
    2020-01-23 xjy02
  8. 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    2019-09-29 smartjoy
  9. 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    2019-09-29 zhang92560
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