JCEM:青少年甲状腺疾病与青年期2型糖尿病风险的关系

2021-06-09 MedSci原创 MedSci原创

在青少年时期诊断的甲状腺疾病是男性和女性早发2型糖尿病的危险因素。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估患有甲状腺疾病的青少年成年期2型糖尿病的风险。

这项全国性的、基于人群的研究对1988-2007年期间入伍前的以色列青少年进行了评估,并一直随访至2016年12月31日。该研究的参与者为1382560名青少年(平均年龄为17.3岁)。甲状腺疾病的诊断是基于最近的甲状腺功能检查。数据与以色列国家糖尿病登记处进行链接,研究人员采用Cox比例风险模型进行分析。该研究的主要结局指标为2型糖尿病的发病率。

在平均18.5年的随访中,伴有甲状腺疾病的青少年中有1.12%(6152人中有69人)的患者被诊断为2型糖尿病,而没有甲状腺疾病的青少年中有0.77%被诊断为2型糖尿病。

甲状腺疾病与青年期2型糖尿病风险的关系

校正性别、出生年龄、BMI和社会人口统计学混杂因素后,甲状腺疾病患者2型糖尿病的HR为2.3 (95%CI为1.8-2.9)。无论男性还是女性,无论是否肥胖,无论是否存在其他健康状况,都可以观察到糖尿病风险增加,并与不同类型的甲状腺疾病相关。当结局被定义为在30岁或之前被诊断的2型糖尿病时,结果也相似(HR为2.3;95%CI为1.5-3.5)。

由此可见,在青少年时期诊断的甲状腺疾病是男性和女性早发2型糖尿病的危险因素

原始出处:

Aya Bardugo.et al.Adolescent Thyroid disorders and Risk for Type 2 Diabetes in Young Adulthood.JCEM.2021.https://doi.org/10.1210/clinem/dgab382

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    2022-04-02 achengzhao
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    2022-02-22 smallant2015
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  5. 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    2021-06-10 ms8000002129803377

    谢谢分享

    0

  6. 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    2021-06-09 小小康

    学习

    0

  7. 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    2021-06-09 ms4000001114161496

    青少年糖尿饼

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210609/c1aa5fe75636431a9c4cb3fd693baaa7/65dd51bca3e04d9784f1099e72c0f75f.jpg, createdBy=a1b25511415, createdName=小小康, createdTime=Wed Jun 09 12:05:22 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972125, encodeId=d2309e21257f, content=青少年糖尿饼, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c8e5452710, createdName=ms4000001114161496, createdTime=Wed Jun 09 11:44:43 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043634, encodeId=5a411043634c8, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jun 09 11:13:57 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972115, encodeId=5c5f9e2115d5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bc242586156, createdName=276206642, createdTime=Wed Jun 09 11:04:59 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972107, encodeId=c50f9e210773, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2021-06-09 misszhang

    谢谢MedSci提供最新的资讯

    0

  9. 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level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jun 09 11:13:57 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972115, encodeId=5c5f9e2115d5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bc242586156, createdName=276206642, createdTime=Wed Jun 09 11:04:59 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972107, encodeId=c50f9e210773, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2021-06-09 276206642

    学习

    0

  10. 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    2021-06-09 j3x

    学习

    0

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