DDS: Barrett食管的早期诊断能改善食管腺癌的生存率

2018-11-19 MedSci MedSci原创

降低食管腺癌(EA)死亡率的有效途径是早期发现Barrett食管(BE),因此本项研究试图确定EA患者早期被诊断出BE的概率,并评估早期BE诊断对EA患者死亡率的影响。

背景及目的
降低食管腺癌(EA)死亡率的有效途径是早期发现Barrett食管(BE),因此本项研究试图确定EA患者早期被诊断出BE的概率,并评估早期BE诊断对EA患者死亡率的影响。

方法
这是一项回顾性队列研究,研究人员对2002 - 2016年期间被诊断为EA的患者进行了回顾性研究。研究人员比较了有或没有早期进行BE诊断的EA患者的EA分期和治疗接受的情况,并使用Cox比例风险模型比较未调整的死亡风险并调整阶段和治疗以评估其影响生存的差异。

结果
在8564名EA患者中,只有4.9%有BE诊断史。早期BE诊断的比例从2005 - 2007年诊断的EA患者中的3.2%增加到2014 - 2016年的7.0%。早期进行BE诊断的EA患者更可能患有1期疾病并接受药物治疗。早期BE诊断与较低的全因死亡率风险相关(危险比[HR],0.69; 95%CI,0.61-0.80)。

结论
早期BE诊断与EA患者更好的生存率相关,临床工作中建议内镜医生应密切关注食管病变。

原始出处:

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    2019-02-09 ysjykql
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    2018-11-21 zhouqu_8
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    2018-11-21 docwu2019

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