Diabetes Care:孕早期妊娠期糖尿病孕妇妊娠结局堪忧

2015-12-19 Seven L 译 MedSci原创

近年来有指南建议对妊娠不到24周的高危妊娠期糖尿病孕妇进行血糖监测,不过目前关于早期识别和治疗妊娠期糖尿病的数据有限。研究者进行了一项研究,调查<24周孕诊断为妊娠期糖尿病的流行率、临床特征、妊娠结局,同时对糖尿病合并妊娠与≥24周后的妊娠期糖尿病进行比较。该研究纳入了1991-2011年的4873名孕产妇,65名为糖尿病合并妊娠,68名妊娠<12周诊断为妊娠期糖尿病,在12-23周诊断为妊娠期糖

近年来有指南建议对妊娠不到24周的高危妊娠期糖尿病孕妇进行血糖监测,不过目前关于早期识别和治疗妊娠期糖尿病的数据有限。研究者进行了一项研究,调查<24周孕诊断为妊娠期糖尿病的流行率、临床特征、妊娠结局,同时对糖尿病合并妊娠与≥24周后的妊娠期糖尿病进行比较。

该研究纳入了1991-2011年的4873名孕产妇,65名为糖尿病合并妊娠,68名妊娠<12周诊断为妊娠期糖尿病,在12-23周诊断为妊娠期糖尿病的有1247人,还有3493名孕产妇≥24周诊断为妊娠期糖尿病。

妊娠期高血压疾病、早产、剖宫产、新生儿黄疸(所有的P值<0.001)在糖尿病合并妊娠和早期妊娠期糖尿病孕产妇中更常见。<12周诊断为妊娠期糖尿病的孕产妇与糖尿病合并妊娠的相比较:巨大儿(21.8% vs. 20.3%, P = 0.8)、大于胎龄儿 (39.6% vs. 32.8%, P = 0.4)、新生儿住进ICU(38.5% vs. 39.7%, P = 0.9)。

尽管目前关于早期妊娠期糖尿病的诊疗技术日趋成熟,但其导致的妊娠结局仍不乐观。<12周诊断为妊娠期糖尿病的孕产妇其妊娠结局与糖尿病合并妊娠没有多大差异。该研究表明,在以后还需要更多的研究和努力,针对该类高危孕妇建立其他的管理以改善妊娠结局。

原始出处:

Sweeting AN, Ross GP,et al.Gestational Diabetes Mellitus in Early Pregnancy: Evidence for Poor Pregnancy Outcomes Despite Treatment.Diabetes Care. 2015 Dec 8. pii: dc150433.


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    2015-12-29 xyfg98

    赞一个

    0

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target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Mon Dec 21 04:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=)]
    2015-12-27 wzf990214

    有意思

    0

  5. 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target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Mon Dec 21 04:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=)]
    2015-12-27 wzf990214

    赞一个

    0

  6. 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  7. 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目前临床上有许多关于妊娠期糖尿病和代谢的研究,例如孕期体重增长情况对以后代谢的影响。但是关于体重改变的时间段绝大多数集中在妊娠期这个时期,而近期Li W等人则着眼于从妊娠期到产后这个跨度,对妊娠期糖尿病的中国女性进行了一项调查,探究孕前到产后1-5年体重的变化和代谢综合征的关系。而代谢综合征是指人体的蛋白质、脂肪、碳水化合物等物质发生代谢紊乱的病理状态,是一组复杂的代谢紊乱症候群,是导致糖尿病心脑

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妊娠期间的糖尿病有两种情况,一种为妊娠前已确诊患糖尿病,称“糖尿病合并妊娠”;另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病,又称为“妊娠期糖尿病(GDM)”。糖尿病孕妇中80%以上为GDM,糖尿病合并妊娠者不足20%。GDM发生率世界各国报道为1%~14%,我国发生率为1%~5%,近年有明显增高趋势。最近有研究表明男性胎儿会降低孕妇胰岛β细胞功能,从而增加妊娠期糖尿病(G

Obstet Gynecol:两种妊娠期糖尿病筛查方案的比较

研究者进行了一项研究,比较两种不同妊娠期糖尿病筛查方案(IADPSG推荐的一步筛查法和Carpenter-Coustan两步筛查法)对母婴结局的影响。该研究纳入了均为单胎妊娠孕妇,所有诊断为妊娠期糖尿病的女性均进行强化教育、家庭血糖检测、以及按需使用药物。以大于胎龄儿发生率作为初始结局指标,巨大儿、首次剖宫产、新生儿住进ICU、早产、子痫前期、高胆红素血症作为继发结局指标。研究数据显示Carpen

Diabetes Care:孕早期腹部脂肪,有助于妊娠期糖尿病高危人群的识别

最新研究表明,孕早期腹部脂肪的增加或导致妊娠期糖尿病风险的增加。该研究纳入了500名女性,年龄18-42岁,通过超声测量孕11-14周的腹部脂肪情况。数据显示腹部脂肪越多的女性在孕24-28周诊断为妊娠期糖尿病的可能性越大。但是该研究仅仅提供了两者间的相关性,并不是因果性。该研究强调了孕早期的筛查,通过腹部脂肪预测糖尿病发生情况。仅仅在常规产前检查的时候,留意下孕早期女性腹部脂肪情况,就可以识别妊

Obstet Gynecol:超声过度诊断“大于胎龄儿”会增加剖宫产风险

糖尿病孕妇孕妇最常见的是羊水过多与胎儿过大。对于胎儿的评估,因为其在孕妇肚子里,只有通过B超看到胎儿情况,根据二维条件下的检测指标,对胎儿生长发育进行评估。而超声对胎儿体重的评估会影响到孕妇分娩方式的选择。Scifres CM等人进行了一项研究,评估对于妊娠期糖尿病孕妇,对其胎儿超声诊断为“大于胎龄儿(LGA)”的准确性,以及因该诊断而导致接下来的剖宫产风险。研究者对903名GDM孕妇进行了一项回

MNT:高危孕妇妊娠期糖尿病是可以预防的

高危孕妇妊娠期糖尿病是可以预防的世界范围内,肥胖和超重的发病率一直在上升,发达国家中存在高达60%的育龄妇女超重或肥胖。肥胖是妊娠并发症(如妊娠期糖尿病GDM)的危险因素,而GDM发过来又可预测未来糖尿病的发生。妊娠期糖尿病及孕妇肥胖还可能增加其后代肥胖的易感性,并损伤机体的糖调节功能。因此,亟需一种有效干预措施以预防GDM的发生。然而,既往GDM预防研究的结果并不一致,对GDM发病率的影响也较小